Toe brachial index predicts major acute cardiovascular events in patients with type 2 diabetes independently of arterial stiffness

Our aim was to analyze the predictive value of toe brachial index (TBI) as a risk marker for future major adverse cardiovascular events (MACE) and all-cause mortality in patients with type 2 diabetes (T2D). TBI was measured in 741 patients with T2D in 2005–2008. Conventional risk factors for vascula...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2020-03, Vol.161, p.108040-108040, Article 108040
Main Authors: Chisalita, Simona I., Wijkman, Magnus, Davidson, Lee Ti, Spångeus, Anna, Nyström, Fredrik, Östgren, Carl Johan
Format: Article
Language:English
Subjects:
Cardiovascular events
Toe brachial index
Toe pressure
Type 2 diabetes
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Summary:Our aim was to analyze the predictive value of toe brachial index (TBI) as a risk marker for future major adverse cardiovascular events (MACE) and all-cause mortality in patients with type 2 diabetes (T2D). TBI was measured in 741 patients with T2D in 2005–2008. Conventional risk factors for vascular disease as well as non-invasive measurements such as pulse-wave velocity (PWV) and intima-media thickness (IMT) of the carotid arteries were estimated. MACE was defined as cardiovascular death or hospitalization for non fatal myocardial infarction or non fatal stroke. Patients were followed for incidence of MACE using the national Swedish Cause of Death Registry and the Inpatient Register. During the follow-up for a period of 9 years MACE occurred in 97 patients and 85 patients died. TBI tertile, 1 versus 3, was significantly related to MACE (HR 2.67, 95%CI 1.60–4.50; p 
ISSN:0168-8227
1872-8227
1872-8227
DOI:10.1016/j.diabres.2020.108040