Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta‐analysis

Background Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re‐assessing of significant results in meta‐analyses. We summarized published meta‐analyses that assess the associations between miRNA polymorphism and cancers to show the v...

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Published in:European journal of clinical investigation 2020-04, Vol.50 (4), p.e13203-n/a
Main Authors: Park, Jae Hyon, Jeong, Gwang Hun, Lee, Kwang Seob, Lee, Keum Hwa, Suh, Jin‐Soon, Eisenhut, Michael, Vliet, Hans J., Kronbichler, Andreas, Stubbs, Brendon, Solmi, Marco, Dragioti, Elena, Koyanagi, Ai, Shin, Jae Il, Gamerith, Gabriele
Format: Article
Language:English
Subjects:
Cancer
Conditional probability
FPRP
Gene polymorphism
gene variant
Genes
Genetic diversity
Genetic Predisposition to Disease
Genetic Variation
Health risks
Humans
Meta-analysis
Meta-Analysis as Topic
microRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Neoplasms - genetics
Nucleotides
Polymorphism
Polymorphism, Single Nucleotide
Reproducibility of Results
Ribonucleic acid
RNA
Single-nucleotide polymorphism
Statistical analysis
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Summary:Background Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re‐assessing of significant results in meta‐analyses. We summarized published meta‐analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the findings. Method We searched PubMed and investigated the results of meta‐analyses published through November 2018. We re‐assessed the results based on false‐positive report probability (FPRP) to test the noteworthiness of the associations. Results Sixty‐eight miRNA polymorphisms in 45 meta‐analyses associated with cancer were included. Four (7.4%) and sixteen (25.0%) single nucleotide polymorphisms (SNPs) were noteworthy (FPRP 
ISSN:0014-2972
1365-2362
1365-2362
DOI:10.1111/eci.13203