Male reproductive health and intergenerational metabolic responses from a small RNA perspective

The world has recently experienced a decline in male reproductive (e.g. sperm counts and motility) and metabolic (e.g. obesity and diabetes) health. Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors...

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Bibliographic Details
Published in:Journal of internal medicine 2020-09, Vol.288 (3), p.305-320
Main Authors: Nätt, D., Öst, A.
Format: Article
Language:English
Subjects:
Animal models
cell biology
Diabetes mellitus
diet
Epididymis
Epigenesis, Genetic
epigenetic inheritance
Humans
Infertility
Male
Metabolic disorders
Metabolic response
Metabolic syndrome
Metabolic Syndrome - genetics
Metabolism
Mitochondria
Obesity
Offspring
Paternal Inheritance
Physical exercise
reproduction
Reproductive Health
RNA, Small Untranslated - genetics
rRNA
small RNA
Sperm
Sperm Count
Sperm Motility
Spermatogenesis
Spermatogenesis - genetics
Spermatozoa
tRNA
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Summary:The world has recently experienced a decline in male reproductive (e.g. sperm counts and motility) and metabolic (e.g. obesity and diabetes) health. Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors for such paternal intergenerational metabolic responses (IGMRs) involve small noncoding RNAs (sncRNAs) that often increase in spermatozoa during the last days of maturation in the epididymis. We and others have shown that the metabolic state – depending on factors such as diet, obesity and physical exercise – may affect sperm quality and sperm sncRNA. Together, this suggests that there are overlapping aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses. In this review, we present a theoretical framework for an overlap of these aetiologies by exploring the advances in our understanding of the roles of sncRNA in spermatogenesis and offspring development. A special focus will lie on novel findings about tRNA‐derived small RNA (tsRNA), rRNA‐derived small RNA (rsRNA) and small mitochondrial RNA (mitoRNA), and their emerging roles in intergenerational metabolic and reproductive health.
ISSN:0954-6820
1365-2796
1365-2796
DOI:10.1111/joim.13096