Analysis of the MCTP Amino Acid Sequence Reveals the Conservation of Putative Calcium- and Lipid-Binding Pockets Within the C2 Domains In Silico

MCTPs (Multiple C2 Domains and Transmembrane region Proteins) are evolutionarily and structurally related to other C2 proteins, which are central to exocytosis and membrane trafficking; however, their specific function has been little studied. MCTPs are associated with endosomes and the endoplasmic...

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Bibliographic Details
Published in:Journal of molecular evolution 2022-08, Vol.90 (3-4), p.271-282
Main Authors: Téllez-Arreola, José Luis, Martínez-Torres, Ataúlfo, Flores-Moran, Adriana E., Lazaro-Guevara, José M., Estrada-Mondragón, Argel
Format: Article
Language:English
Subjects:
Amino acid sequence
Amino acids
Animal Genetics and Genomics
Binding
Biomedical and Life Sciences
Calcium
Calcium ions
Cell Biology
Conserved sequence
Coronary vessels
Endoplasmic reticulum
Endosomes
Evolution
Evolutionary Biology
Exocytosis
Gene expression
Heart
Kinases
Life Sciences
Lipids
Maximum likelihood method
Membrane trafficking
Membranes
Microbiology
Original Article
Phylogenetics
Physiology
Plant Genetics and Genomics
Plant Sciences
Proteins
Structural models
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Summary:MCTPs (Multiple C2 Domains and Transmembrane region Proteins) are evolutionarily and structurally related to other C2 proteins, which are central to exocytosis and membrane trafficking; however, their specific function has been little studied. MCTPs are associated with endosomes and the endoplasmic reticulum and possess three C2 domains (C2A-C2C) and two transmembrane regions (TMRs) well conserved in different species. Here, we generated structural models of the MCTP C2 domains of C. elegans and analyzed their putative function by docking, which revealed that these domains possess Ca 2+ - and lipid-binding pockets, suggesting that MCTPs play a significant, calcium-dependent role in membrane physiology.
ISSN:0022-2844
1432-1432
1432-1432
DOI:10.1007/s00239-022-10057-1