Calcium complexes of oxicams: new dimensions in rheumatoid arthritis treatment

Various metals have been complexed with drugs to improve their cellular impact. Inflammatory diseases like rheumatoid arthritis (RA) are characterized by unbalanced production of proinflammatory cytokines (PICs) and prostaglandins with decreased levels of vitamin D and calcium. The inflammation can...

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Bibliographic Details
Published in:Future medicinal chemistry 2022-12, Vol.14 (23), p.1771-1788
Main Authors: Sadia, Aatika, Yasmin, Tahira, Imran, Muhammad, Samra, Malka M, Raza Basra, Muhammad Asim
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antirheumatic Agents - pharmacology
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Calcium
Cyclooxygenase Inhibitors
Cytokines
Humans
inflammation
metal–drug complexes
NSAIDs
proinflammatory cytokines
synovium
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Summary:Various metals have been complexed with drugs to improve their cellular impact. Inflammatory diseases like rheumatoid arthritis (RA) are characterized by unbalanced production of proinflammatory cytokines (PICs) and prostaglandins with decreased levels of vitamin D and calcium. The inflammation can be suppressed through targeting the formation of PICs or related enzymes by various treatment strategies that involve the use of corticosteroids, disease-modifying antirheumatic drugs and NSAIDs. We present a detailed review on the impact of calcium complexes of oxicams as an advanced treatment strategy for RA. The calcium complexes demonstrate promising capabilities to cure the disease, improve the strength of bones and suppress PICs in RA.
ISSN:1756-8919
1756-8927
1756-8927
DOI:10.4155/fmc-2022-0032