Ag/AgCl Decorated Ionic Liquid@Tantalum Pentoxide Nanostructures: Fabrication, Photocatalytic Activity, and Cytotoxicity Effects Against Human Brain Tumor Cells

• Published in: Journal of inorganic and organometallic polymers and materials 2023-09, Vol.33 (9), p.2647-2660
• Main Authors: Dawi, E. A., Mustafa, E., Padervand, M., Ashames, A., Hajiahmadi, S., Saleem, L., Baghernejad, M., Nur, O., Willander, M.
• Format: Article
• Language: English
• Subjects: Biocompatibility; Brain; Catalytic activity; Cell death; Chemistry; Chemistry and Materials Science; Contaminants; Current carriers; Cytotoxicity; Drinking water; Dyes; Electron microscopy; Electron paramagnetic resonance; Electron spin; Infrared spectroscopy; Inorganic Chemistry; Ionic liquids; Microscopy; Nanomaterials; Nanoparticles; Nanostructure; Organic Chemistry; Photocatalysis; Photocatalysts; Photoluminescence; Polymer Sciences; Room temperature; Spectrum analysis; Spin resonance; Toxicity; Tumors; Water quality
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-023-02693-x

Environmental contaminants have become a major concern for human beings due to their adverse effects on drinking water quality. Heterogeneous photocatalysis has been extensively investigated as a potential strategy to minimize the consequences of as-related processes. Using a room-temperature ionic liquid-mediated co-precipitation method, Ag@AgCl nanoparticles were loaded onto tantalum pentoxide to make a plasmonic photocatalyst to remove Congo Red dye. The physicochemical properties of the photocatalysts were characterized by X-ray diffraction powder (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Diffuse Reflectance Spectroscopy (DRS), Fourier-transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM), photoluminescence (PL), and nitrogen adsorption–desorption isotherms. The results indicate that 96% of the dye was degraded within 20 min with a rate constant of 0.14 min −1 . The key radicals involved in the photocatalysis, recognized as O 2 ·– species, were identified by electron spin resonance (ESR) in the presence of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), as the spin trapping agent. Our findings and quenching experiments elucidates the mechanism of the charge carrier migration. The cytotoxicity activity of the nanostructures was also examined against human brain glioblastoma tumor cells for the first time. A precise analysis of the cell death pathway was conducted using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and caspase activity assays in combination with fluorescence microscopy images. The prepared nanomaterials were found to be promising candidates for treating the organic pollutants and biomedical waste effluents from academic and industrial activities.