Coronary Artery Stenosis Evaluation by Angiography-Derived FFR: Validation by Positron Emission Tomography and Invasive Thermodilution

Fractional flow reserve (FFR) derived from invasive coronary angiography (QFR) is promising for evaluation of intermediate coronary artery stenosis. The authors aimed to compare the diagnostic performance of QFR and the guideline-recommended invasive FFR using Rubidium positron emission tomography (...

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Published in:JACC. Cardiovascular imaging 2023-10, Vol.16 (10), p.1321-1331
Main Authors: Westra, Jelmer, Rasmussen, Laust Dupont, Eftekhari, Ashkan, Winther, Simon, Karim, Salma Raghad, Johansen, Jane Kirk, Hammid, Osama, Søndergaard, Hanne Maare, Ejlersen, June Anita, Gormsen, Lars C, Mogensen, Lone Juul Hune, Bøttcher, Morten, Holm, Niels Ramsing, Christiansen, Evald Høj
Format: Article
Language:English
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Summary:Fractional flow reserve (FFR) derived from invasive coronary angiography (QFR) is promising for evaluation of intermediate coronary artery stenosis. The authors aimed to compare the diagnostic performance of QFR and the guideline-recommended invasive FFR using Rubidium positron emission tomography ( Rb-PET) myocardial perfusion imaging as reference standard. This is a prospective, observational study of symptomatic patients with suspected obstructive coronary artery disease on coronary computed tomography angiography (≥50% diameter stenosis in ≥1 vessel). All patients were referred to Rb-PET and invasive coronary angiography with FFR and QFR assessment of all intermediate (30%-90% diameter stenosis) stenoses. Main analyses included a comparison of the ability of QFR and FFR to identify reduced myocardial blood flow (
ISSN:1936-878X
1876-7591
1876-7591
DOI:10.1016/j.jcmg.2023.02.008