Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET)

• Published in: World journal of urology 2024-11, Vol.42 (1), p.654
• Main Authors: Hedlund, Petter, Rahardjo, Harrina E., Tsikas, Dimitrios, Kuczyk, Markus A., Ückert, Stefan
• Format: Article
• Language: English
• Subjects: 3',5'-Cyclic-nucleotide phosphodiesterase; Adrenergic beta-Antagonists - pharmacology; Adrenergic beta-Antagonists - therapeutic use; Adrenergic receptors; Antagonists; Calcium antagonists; Calcium Channel Blockers - pharmacology; Calcium Channel Blockers - therapeutic use; Calcium oxide; Drug development; Drugs; Enzyme inhibitors; Humans; Isoenzymes; Kinases; Lithiasis; Medicine; Medicine & Public Health; Muscle contraction; Muscle, Smooth - drug effects; Nephrology; Nitric oxide; Nitric Oxide Donors - pharmacology; Nitric Oxide Donors - therapeutic use; Oncology; Phosphodiesterase; Phosphodiesterase Inhibitors - pharmacology; Phosphodiesterase Inhibitors - therapeutic use; Potassium; Review; Rho-associated kinase; Signal transduction; Smooth muscle; Ureter; Ureter - drug effects; Ureteral Calculi - drug therapy; Urology
• ISSN: 0724-4983; 1433-8726; 1433-8726
• DOI: 10.1007/s00345-024-05368-5

Purpose Urolithiasis and symptomatic ureterolithiasis represent diseases known to be on the increase in most westernized countries. The present article aims to give an overview on some drug principles assumed to target signalling systems involved in modulating ureter smooth muscle contractility and to present background to their potential use or prospects in ureter stone disease. Methods The article reviews drugs that have been evaluated over the last decades in vitro, in vivo and/or in clinical settings with regard to their properties to achieve spontaneous passage of (distal) ureteral stones and relieve colic pain. Among these drugs are alpha- and beta-adrenoceptor antagonists, calcium channel blocking agents, Rho kinase inhibitors, nitric oxide (NO) donor drugs, selective inhibitors of cyclic nucleotide phosphodiesterase enzymes (PDEs), as well as potassium channel openers. Results Based on the recent scientific information on agents targeting different pathways, antagonists of alpha 1-adrenoceptors, inhibitors of the PDE isoenzymes PDE4 and PDE5 (affecting cyclic AMP- or NO/cyclic GMP-mediated signals that facilitate relaxation of ureter smooth muscle), as well as the combination of certain drugs (for example, PDE5/PDE4 inhibitor plus alpha 1-AR antagonist) seem to be intriguing pharmacological approaches to medical expulsion therapy (MET) in the overall population of patients. Conclusion While NO donors, calcium channel antagonists and potassium channel openers may be limited for further development for medical expulsion therapy (MET) due to their systemic effects and a lack of effect on stone clearance, Rho kinase inhibitors should be explored further as a future pharmacological principle in ureteral stone disease.