Mechanisms of ventilation inhomogeneity during vital capacity breaths standing and supine

Overall inhomogeneity of ventilation distribution, as measured by single-breath vital capacity (VC) washout (SBW) is known to be greater supine vs. standing. To establish the underlying mechanisms 13 healthy males performed VC SBW of 4% SF 6 and He, standing and supine, with or without a 10 sec brea...

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Bibliographic Details
Published in:Respiration physiology 2002, Vol.129 (3), p.345-355
Main Authors: Grönkvist, Mikael J, Emery, Michael J, Gustafsson, Per M
Format: Article
Language:English
Subjects:
Adult
Air breathing
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Helium
Heterogeneity
Heterogeneity, regional, lung ventilation
Humans
Inert gases, He, SF 6, exhaled gas
Male
Mammals, humans
MEDICIN
MEDICINE
Middle Aged
Posture - physiology
Posture, ventilation distribution, supine vs. standing
regional
Respiration
Respiratory Mechanics
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
SF6
single-breath
Sulfur Hexafluoride
Supine Position - physiology
Ventilation, distribution
Vertebrates: respiratory system
Vital Capacity
Washout, single-breath
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Summary:Overall inhomogeneity of ventilation distribution, as measured by single-breath vital capacity (VC) washout (SBW) is known to be greater supine vs. standing. To establish the underlying mechanisms 13 healthy males performed VC SBW of 4% SF 6 and He, standing and supine, with or without a 10 sec breathhold (BH). Overall inhomogeneity, as indicated by normalized phase III slopes, was >50% greater supine (SF 6 13.1×10 −3; He 10.7×10 −3 L −1) than standing (SF 6 8.6×10 −3; He 6.4×10 −3 L −1; P
ISSN:0034-5687
1872-7611
DOI:10.1016/S0034-5687(01)00318-8