Limitations of Intraoperative Adrenal Remnant Volume Measurement in Patients Undergoing Subtotal Adrenalectomy

Background Recent studies have shown that a minimum of approximately one-third of one normal adrenal gland is required for sufficient adrenocortical stress capacity. Correlation between intraoperative measurement, determination of remnant size by computed tomography (CT), and adrenocortical stress c...

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Bibliographic Details
Published in:World journal of surgery 2008-05, Vol.32 (5), p.863-872
Main Authors: Brauckhoff, Michael, Stock, Karsten, Stock, Susanne, Lorenz, Kerstin, Sekulla, Carsten, Brauckhoff, Katrin, Thanh, Phuong Nguyen, Gimm, Oliver, Spielmann, Rolf Peter, Dralle, Henning
Format: Article
Language:English
Subjects:
Abdominal Surgery
ACTH Test
Adolescent
Adrenal Cortex Function Tests
Adrenal Gland Diseases - diagnosis
Adrenal Gland Diseases - physiopathology
Adrenal Gland Diseases - surgery
Adrenal Glands - diagnostic imaging
Adrenal Glands - pathology
Adrenal Glands - physiopathology
Adrenal Tissue
Adrenal Volume
Adrenalectomy
Adrenocortical Function
Adult
Aged
Biological and medical sciences
Cardiac Surgery
Cohort Studies
Female
General aspects
General Surgery
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
NATURAL SCIENCES
NATURVETENSKAP
Normal Adrenal Tissue
Organ Size
Recovery of Function
Reproducibility of Results
Surgery
Thoracic Surgery
Tomography, X-Ray Computed
Vascular Surgery
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Summary:Background Recent studies have shown that a minimum of approximately one-third of one normal adrenal gland is required for sufficient adrenocortical stress capacity. Correlation between intraoperative measurement, determination of remnant size by computed tomography (CT), and adrenocortical stress capacity has not been examined so far. Methods Twenty-two patients with familial pheochromocytoma (n = 13), sporadic pheochromocytoma (n = 3), and adrenocortical tumors (n = 6) who underwent unilateral or bilateral subtotal adrenalectomy (STAE, 28 adrenal remnants) were prospectively studied. Patients were examined in a multi-slice CT to determine residual adrenal tissue and by ACTH test 4 days and 3 months postoperatively. Results There was a slight significant correlation between intraoperative and CT calculated volumes ( r  = 0.77; p  
ISSN:0364-2313
1432-2323
1432-2323
DOI:10.1007/s00268-007-9402-y