Antibody Prevalence and Titer to Norovirus (Genogroup II) Correlate with Secretor (FUT2) but Not with ABO Phenotype or Lewis (FUT3) Genotype

• Published in: The Journal of infectious diseases 2006-11, Vol.194 (10), p.1422-1427
• Main Authors: Larsson, Malin Modin, Rydell, Gustaf E. P., Grahn, Ammi, Rodríguez-Díaz, Jesús, Åkerlind, Britt, Hutson, Anne M., Estes, Mary K., Larson, Göran, Svensson, Lennart
• Format: Article
• Language: English
• Subjects: ABO Blood-Group System; Adult; Aged; Antibodies; Antibodies, Viral - blood; Antigens; Biological and medical sciences; Blood Group Antigens - analysis; Blood grouping; Caliciviridae Infections - genetics; Caliciviridae Infections - immunology; Fucosyltransferases - genetics; Fundamental and applied biological sciences. Psychology; Galactoside 2-alpha-L-fucosyltransferase; Genotypes; Humans; Immunity, Innate - genetics; Immunoglobulin G - blood; Infections; Infectious diseases; Medical sciences; MEDICIN; MEDICINE; Microbiology; Microbiology, immunology, infectious diseases; Middle Aged; Mikrobiologi; Mikrobiologi, immunologi, infektionssjukdomar; Norovirus; Norovirus - immunology; Norwalk virus; Phenotypes; Rotavirus; Statistics as Topic; Virologi; Virology; Viruses
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1086/508430

BackgroundHisto–blood group antigens and secretor status have been associated with susceptibility to Norovirus infections, which suggests that antibody prevalence and titer might correlate with these phenotypes MethodsPlasma samples (n=105) from Swedish blood donors that had been genotyped for secretor (FUT2) and Lewis (Le; FUT3) genotypes and phenotyped for ABO and Le blood groups were analyzed for immunoglobulin G antibody prevalence and titers to norovirus genogroup (GG) II.4 ResultsThe results showed that nonsecretors (se428se428) and Lea+b− individuals not only had significantly lower antibody titers than did secretors (P