Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas

Ki‐67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except Go. In the present study, Ki‐67 expression in 255 human colorectal adenocarcinomas was examined using immunohistochemistry with the monoclonal antibody MIB‐1. One hundred and fifty‐seven (...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 1997-07, Vol.105 (7-12), p.730-734
Main Authors: JANSSON, AGNETA, SUN, XIAO-FENG
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - immunology
Adenocarcinoma - pathology
Age Factors
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
Cell Cycle
Cell Differentiation
colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - immunology
Colorectal Neoplasms - pathology
DNA, Neoplasm - analysis
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
immunohistochemistry
Ki-67
Ki-67 Antigen
Male
Medical sciences
MEDICIN
MEDICINE
Middle Aged
Prognosis
Sex Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Ki‐67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except Go. In the present study, Ki‐67 expression in 255 human colorectal adenocarcinomas was examined using immunohistochemistry with the monoclonal antibody MIB‐1. One hundred and fifty‐seven (62%) cases had more than 50% positive tumour cells and 98 (38%) cases less than 50%. The tumours showed a wide range of Ki‐67 expression, from 13% to 90%, which indicated a variation in proliferative activity. There was no significant relationship between Ki‐67 expression and sex, age, tumour location, Dukes' stage, growth pattern, differentiation, DNA content, S‐phase fraction or survival (p>0.05). In conclusion, the proliferative activity as measured by Ki‐67 antibody was not related to clinicopathology and prognosis in colorectal cancer.
ISSN:0903-4641
1600-0463
1600-0463
DOI:10.1111/j.1699-0463.1997.tb05078.x