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Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county
The purpose of this study was to investigate if multiresistant methicillin-susceptible Staphylococcus aureus (MR-MSSA) causing a clonal outbreak in Östergötland County, Sweden, were derived from methicillin-resistant S. aureus (MRSA) by carrying remnants of SCC mec , and, if so, to characterise this...
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| Published in: | European journal of clinical microbiology & infectious diseases 2012-02, Vol.31 (2), p.141-147 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Lindqvist, M. Isaksson, B. Grub, C. Jonassen, T. Ø. Hällgren, A. |
| description | The purpose of this study was to investigate if multiresistant methicillin-susceptible
Staphylococcus aureus
(MR-MSSA) causing a clonal outbreak in Östergötland County, Sweden, were derived from methicillin-resistant
S. aureus
(MRSA) by carrying remnants of SCC
mec
, and, if so, to characterise this element. A total of 54 MSSA isolates with concomitant resistance to erythromycin, clindamycin and tobramycin from 49 patients (91% clonally related,
spa
type t002) were investigated with the BD GeneOhm MRSA assay and real-time polymerase chain reaction (PCR) targeting the SCC
mec
integration site/SCC
mec
right extremity junction. DNA sequencing of one isolate representing the MR-MSSA outbreak clone was performed by massive parallel 454 pyrosequencing. All isolates that were part of the clonal outbreak carried SCC
mec
remnants. The DNA sequencing revealed the carriage of a pseudo-SCC element 12 kb in size, with a genomic organisation identical to an SCC
mec
type ΙΙ element, except for a 41-kb gap. This study demonstrates the presence of a pseudo-SCC element resembling SCC
mec
type II among MR-MSSA, suggesting possible derivation from MRSA. The presence of SCC
mec
remnants should always be considered when SCC
mec
typing is used for MRSA detection, and may not be suitable in locations with a high prevalence of MR-MSSA, since this might give a high number of false-positive results. |
| doi_str_mv | 10.1007/s10096-011-1286-y |
| format | article |
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Staphylococcus aureus
(MR-MSSA) causing a clonal outbreak in Östergötland County, Sweden, were derived from methicillin-resistant
S. aureus
(MRSA) by carrying remnants of SCC
mec
, and, if so, to characterise this element. A total of 54 MSSA isolates with concomitant resistance to erythromycin, clindamycin and tobramycin from 49 patients (91% clonally related,
spa
type t002) were investigated with the BD GeneOhm MRSA assay and real-time polymerase chain reaction (PCR) targeting the SCC
mec
integration site/SCC
mec
right extremity junction. DNA sequencing of one isolate representing the MR-MSSA outbreak clone was performed by massive parallel 454 pyrosequencing. All isolates that were part of the clonal outbreak carried SCC
mec
remnants. The DNA sequencing revealed the carriage of a pseudo-SCC element 12 kb in size, with a genomic organisation identical to an SCC
mec
type ΙΙ element, except for a 41-kb gap. This study demonstrates the presence of a pseudo-SCC element resembling SCC
mec
type II among MR-MSSA, suggesting possible derivation from MRSA. The presence of SCC
mec
remnants should always be considered when SCC
mec
typing is used for MRSA detection, and may not be suitable in locations with a high prevalence of MR-MSSA, since this might give a high number of false-positive results.</description><identifier>ISSN: 0934-9723</identifier><identifier>ISSN: 1435-4373</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-011-1286-y</identifier><identifier>PMID: 21590357</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotics ; Bacterial diseases ; Bacterial Typing Techniques ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Clindamycin ; Cloning ; Deoxyribonucleic acid ; Disease Outbreaks ; DNA ; DNA sequencing ; DNA Transposable Elements - genetics ; Drug resistance ; Drug Resistance, Multiple, Bacterial ; Erythromycin ; Genes ; genomics ; Human bacterial diseases ; Humans ; Infectious diseases ; Integration ; Internal Medicine ; Medical Microbiology ; Medical sciences ; MEDICIN ; MEDICINE ; Methicillin - pharmacology ; Methicillin Resistance - genetics ; Methicillin-Resistant Staphylococcus aureus - genetics ; Microbial Sensitivity Tests ; Outbreaks ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - classification ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Staphylococcus infections ; Sweden - epidemiology ; Tobramycin ; Typing</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2012-02, Vol.31 (2), p.141-147</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-503e11c951e277e09e8c2af9c00ad6ea97310779dd087225d044923b9a2cdfdc3</citedby><cites>FETCH-LOGICAL-c469t-503e11c951e277e09e8c2af9c00ad6ea97310779dd087225d044923b9a2cdfdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25595223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21590357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-74635$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindqvist, M.</creatorcontrib><creatorcontrib>Isaksson, B.</creatorcontrib><creatorcontrib>Grub, C.</creatorcontrib><creatorcontrib>Jonassen, T. Ø.</creatorcontrib><creatorcontrib>Hällgren, A.</creatorcontrib><title>Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>The purpose of this study was to investigate if multiresistant methicillin-susceptible
Staphylococcus aureus
(MR-MSSA) causing a clonal outbreak in Östergötland County, Sweden, were derived from methicillin-resistant
S. aureus
(MRSA) by carrying remnants of SCC
mec
, and, if so, to characterise this element. A total of 54 MSSA isolates with concomitant resistance to erythromycin, clindamycin and tobramycin from 49 patients (91% clonally related,
spa
type t002) were investigated with the BD GeneOhm MRSA assay and real-time polymerase chain reaction (PCR) targeting the SCC
mec
integration site/SCC
mec
right extremity junction. DNA sequencing of one isolate representing the MR-MSSA outbreak clone was performed by massive parallel 454 pyrosequencing. All isolates that were part of the clonal outbreak carried SCC
mec
remnants. The DNA sequencing revealed the carriage of a pseudo-SCC element 12 kb in size, with a genomic organisation identical to an SCC
mec
type ΙΙ element, except for a 41-kb gap. This study demonstrates the presence of a pseudo-SCC element resembling SCC
mec
type II among MR-MSSA, suggesting possible derivation from MRSA. The presence of SCC
mec
remnants should always be considered when SCC
mec
typing is used for MRSA detection, and may not be suitable in locations with a high prevalence of MR-MSSA, since this might give a high number of false-positive results.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacterial diseases</subject><subject>Bacterial Typing Techniques</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clindamycin</subject><subject>Cloning</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Outbreaks</subject><subject>DNA</subject><subject>DNA sequencing</subject><subject>DNA Transposable Elements - genetics</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Erythromycin</subject><subject>Genes</subject><subject>genomics</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Integration</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Methicillin - pharmacology</subject><subject>Methicillin Resistance - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Outbreaks</subject><subject>Polymerase Chain Reaction</subject><subject>Sequence Analysis, DNA</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - classification</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Staphylococcus infections</subject><subject>Sweden - epidemiology</subject><subject>Tobramycin</subject><subject>Typing</subject><issn>0934-9723</issn><issn>1435-4373</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFktuKFDEQhhtR3HH1AbyRICze2JpDp9O5XGY9wYIXo96GTLp6Jms6GXNgmafxVc044y4I4k0KKt9fVan8TfOc4DcEY_E21VP2LSakJXTo2_2DZkE6xtuOCfawWWDJulYKys6aJynd4KoZhHjcnFHCJWZcLJqfV5DBZBs80n5EZqujNhmiTfp3MkxotVzOYFCE2WufE7IezcVlGyHZlGsKzZC31ljnrG9TSQZ22a4doFXWu-3eBROMKQnpEqEGo0uyfoM0Mi547VAoeR1Bfz9U1mh1C6NNW2RC8Xn_tHk0aZfg2SmeN1_fv_uy_Nhef_7waXl53Zqul7nlmAEhRnICVAjAEgZD9SQNxnrsQUvBCBZCjiMeBKV8xF0nKVtLTc04jYadN6-PddMt7Mpa7aKdddyroK26st8uVYgb5WxRousZr_irI76L4UeBlNVs67ud0x5CSUr2A-klo_j_JOn6vsP9UMmXf5E3ocS6oANUPxQL3lWIHCETQ0oRprtJCVYHU6ijKVQ1hTqYQu2r5sWpcFnPMN4p_rigAhcnQCej3RS1Nzbdc5xLTimrHD0tqV75DcT7Cf_d_RdHFNLQ</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Lindqvist, M.</creator><creator>Isaksson, B.</creator><creator>Grub, C.</creator><creator>Jonassen, T. 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Ø. ; Hällgren, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-503e11c951e277e09e8c2af9c00ad6ea97310779dd087225d044923b9a2cdfdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Bacterial diseases</topic><topic>Bacterial Typing Techniques</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clindamycin</topic><topic>Cloning</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Outbreaks</topic><topic>DNA</topic><topic>DNA sequencing</topic><topic>DNA Transposable Elements - genetics</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Erythromycin</topic><topic>Genes</topic><topic>genomics</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Integration</topic><topic>Internal Medicine</topic><topic>Medical Microbiology</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>MEDICINE</topic><topic>Methicillin - pharmacology</topic><topic>Methicillin Resistance - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Outbreaks</topic><topic>Polymerase Chain Reaction</topic><topic>Sequence Analysis, DNA</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - classification</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - genetics</topic><topic>Staphylococcus infections</topic><topic>Sweden - epidemiology</topic><topic>Tobramycin</topic><topic>Typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindqvist, M.</creatorcontrib><creatorcontrib>Isaksson, B.</creatorcontrib><creatorcontrib>Grub, C.</creatorcontrib><creatorcontrib>Jonassen, T. 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Ø.</au><au>Hällgren, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>31</volume><issue>2</issue><spage>141</spage><epage>147</epage><pages>141-147</pages><issn>0934-9723</issn><issn>1435-4373</issn><eissn>1435-4373</eissn><abstract>The purpose of this study was to investigate if multiresistant methicillin-susceptible
Staphylococcus aureus
(MR-MSSA) causing a clonal outbreak in Östergötland County, Sweden, were derived from methicillin-resistant
S. aureus
(MRSA) by carrying remnants of SCC
mec
, and, if so, to characterise this element. A total of 54 MSSA isolates with concomitant resistance to erythromycin, clindamycin and tobramycin from 49 patients (91% clonally related,
spa
type t002) were investigated with the BD GeneOhm MRSA assay and real-time polymerase chain reaction (PCR) targeting the SCC
mec
integration site/SCC
mec
right extremity junction. DNA sequencing of one isolate representing the MR-MSSA outbreak clone was performed by massive parallel 454 pyrosequencing. All isolates that were part of the clonal outbreak carried SCC
mec
remnants. The DNA sequencing revealed the carriage of a pseudo-SCC element 12 kb in size, with a genomic organisation identical to an SCC
mec
type ΙΙ element, except for a 41-kb gap. This study demonstrates the presence of a pseudo-SCC element resembling SCC
mec
type II among MR-MSSA, suggesting possible derivation from MRSA. The presence of SCC
mec
remnants should always be considered when SCC
mec
typing is used for MRSA detection, and may not be suitable in locations with a high prevalence of MR-MSSA, since this might give a high number of false-positive results.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21590357</pmid><doi>10.1007/s10096-011-1286-y</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2012-02, Vol.31 (2), p.141-147 |
| issn | 0934-9723 1435-4373 1435-4373 |
| language | eng |
| recordid | cdi_swepub_primary_oai_DiVA_org_liu_74635 |
| source | Springer Nature |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotics Bacterial diseases Bacterial Typing Techniques Biological and medical sciences Biomedical and Life Sciences Biomedicine Clindamycin Cloning Deoxyribonucleic acid Disease Outbreaks DNA DNA sequencing DNA Transposable Elements - genetics Drug resistance Drug Resistance, Multiple, Bacterial Erythromycin Genes genomics Human bacterial diseases Humans Infectious diseases Integration Internal Medicine Medical Microbiology Medical sciences MEDICIN MEDICINE Methicillin - pharmacology Methicillin Resistance - genetics Methicillin-Resistant Staphylococcus aureus - genetics Microbial Sensitivity Tests Outbreaks Polymerase Chain Reaction Sequence Analysis, DNA Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - classification Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Staphylococcus infections Sweden - epidemiology Tobramycin Typing |
| title | Detection and characterisation of SCCmec remnants in multiresistant methicillin-susceptible Staphylococcus aureus causing a clonal outbreak in a Swedish county |
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