Bladder Wash Cytology at Diagnosis of Ta-T1 Bladder Cancer Is Predictive for Recurrence and Progression

Objective To evaluate the effect of the bladder wash cytology finding at the primary diagnosis of Stage Ta-T1 urinary bladder cancer on recurrence and progression. Methods The clinical and pathologic characteristics of all patients with primary Stage Ta-T1 urinary bladder cancer were prospectively r...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2012-09, Vol.80 (3), p.625-631
Main Authors: Jancke, Georg, Rosell, Johan, Chebil, Gunilla, Jahnson, Staffan
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Transitional Cell - pathology
Disease Progression
Female
Humans
Male
Medical sciences
MEDICIN
MEDICINE
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Nephrology. Urinary tract diseases
Predictive Value of Tests
Prospective Studies
Therapeutic Irrigation
Tumors of the urinary system
Urinary Bladder - pathology
Urinary Bladder Neoplasms - pathology
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Urology
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Summary:Objective To evaluate the effect of the bladder wash cytology finding at the primary diagnosis of Stage Ta-T1 urinary bladder cancer on recurrence and progression. Methods The clinical and pathologic characteristics of all patients with primary Stage Ta-T1 urinary bladder cancer were prospectively registered. The data were divided according to the bladder wash cytology results at diagnosis. Multivariate analyses were performed to determine the influence of bladder wash cytology on recurrence and progression. Results The analysis included 768 evaluable patients with a mean follow-up of 60 months. Recurrence was observed in 478 patients (62%) and progression in 71 (9%). High-grade malignant bladder wash cytology was predictive for recurrence and progression ( P < .001 and P = .036, respectively). Other factors affecting recurrence were missing bladder wash cytology data, tumors size 16-30 mm and >30 mm, Stage T1 tumor category, and multiplicity ( P = .008, P = .006, P < .001, P = .002, and P < .001, respectively). Progression was also associated with T1 tumor category, local recurrence, and primary concomitant carcinoma in situ ( P < .001, P < .001, and P = .024, respectively). Conclusion High-grade malignant bladder wash cytology at the primary diagnosis was predictive for recurrence and progression. This could be taken into account in designing future follow-up schedules.
ISSN:0090-4295
1527-9995
1527-9995
DOI:10.1016/j.urology.2012.04.049