Consecutive CT in vivo lung imaging as quantitative parameter of influenza vaccine efficacy in the ferret model

Graphical abstract Highlights ► We evaluated efficacy of an influenza vaccine by means of CT-scan in the ferret. ► Longitudinal in vivo scanning allows quantification of changes in aerated lung volume. ► Immunisation protects from a significant initial severe increase in aerated lung volume seen in...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2012-12, Vol.30 (51), p.7391-7394
Main Authors: Veldhuis Kroeze, Edwin J.B, Stittelaar, Koert J, Teeuwsen, Vera J, Dijkshoorn, Marcel L, van Amerongen, Geert, de Waal, Leon, Kuiken, Thijs, Krestin, Gabriel P, Hinkula, Jorma, Osterhaus, Albert D.M.E
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
blood serum
computed tomography
CT scan
Disease Models, Animal
Drug Discovery - methods
Female
Ferret
Ferrets
image analysis
In vivo imaging
Influenza
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza virus
Lung - diagnostic imaging
Lung - pathology
Mustela putorius furo
necropsy
Orthomyxoviridae
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - prevention & control
pandemic
Pathology
Pathology - methods
Placebos - administration & dosage
Preclinical vaccine efficacy
Tomography, X-Ray Computed - methods
Treatment Outcome
vaccination
vaccines
viral load
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Graphical abstract Highlights ► We evaluated efficacy of an influenza vaccine by means of CT-scan in the ferret. ► Longitudinal in vivo scanning allows quantification of changes in aerated lung volume. ► Immunisation protects from a significant initial severe increase in aerated lung volume seen in unprotected controls. ► Immunisation protects from major increase of relative lung weight.
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2012.10.008