Orthostatic hypotension in organic dementia: relationship between blood pressure, cortical blood flow and symptoms

Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marke...

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Bibliographic Details
Published in:Clinical autonomic research 1996-02, Vol.6 (1), p.29-36
Main Authors: Passant, U, Warkentin, S, Karlson, S, Nilsson, K, Edvinsson, L, Gustafson, L
Format: Article
Language:English
Subjects:
Aged
Blood Pressure
Cerebral Cortex - blood supply
Cerebrovascular Circulation
Dementia - complications
Dementia - physiopathology
Female
Humans
Hypotension, Orthostatic - complications
Hypotension, Orthostatic - physiopathology
Male
Middle Aged
Supine Position
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Summary:Regional cerebral blood flow was measured in 35 patients with organic dementia (Alzheimer's disease, n = 13, vascular dementia, n = 17, frontotemporal dementia, n = 5) and orthostatic hypotension. Measurements were performed during supine rest and during head-up tilt (60 degrees). Despite marked blood pressure falls, few patients had symptoms of orthostatic hypotension. All three dementia groups had a decrease in regional cerebral blood flow in the frontal lobes during head-up tilt, but no change in mean hemispheric flow. All patients had a consistent drop in their systolic blood pressure upon head-up tilt, with a wide variation over time. The findings suggest that orthostatic hypotension needs to be considered, and actively sought for, in organic dementia as many patients may lack the typical symptoms of orthostatic hypotension, despite a marked fall in blood pressure.
ISSN:0959-9851
1619-1560
1619-1560
DOI:10.1007/BF02291403