Proteomic approaches to identify circulating biomarkers in patients with abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a common condition with high mortality when ruptured. Most clinicians agree that small AAAs are best managed by ultrasonographic surveillance. However, it has been stated in recent reviews that a serum/plasma biomarker that predicts AAA rupture risk would be a powe...

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Bibliographic Details
Published in:American journal of cardiovascular disease 2015-01, Vol.5 (3), p.140-145
Main Authors: Bylund, Dan, Henriksson, Anders E
Format: Article
Language:English
Subjects:
Aortic aneurysm
biomarker
proteomics
Review
Online Access:Get full text
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Summary:Abdominal aortic aneurysm (AAA) is a common condition with high mortality when ruptured. Most clinicians agree that small AAAs are best managed by ultrasonographic surveillance. However, it has been stated in recent reviews that a serum/plasma biomarker that predicts AAA rupture risk would be a powerful tool in stratifying patients with small AAAs. Identification of such circulating biomarkers with traditional hypothesis driven studies has been unsuccessful. In this review we summarize six studies using different proteomic approaches to find new, potential plasma AAA biomarker candidates. In conclusion, by using proteomic approaches novel potential plasma biomarkers for AAA have been identified.
ISSN:2160-200X
2160-200X