Insufficient use of menopausal hormone therapy in Swedish women with early or premature menopause caused by bilateral oophorectomy: a register‐based study

Objective To investigate the use of menopausal hormone therapy (MHT) in premenopausal women after bilateral oophorectomy. Design Retrospective register‐based cohort study. Setting Sweden. Population Swedish women aged 35–44 years without malignancy who underwent bilateral oophorectomy in 2005–2020 w...

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Published in:BJOG : an international journal of obstetrics and gynaecology 2024-03, Vol.131 (4), p.500-507
Main Authors: Sundell, Micaela, Brynhildsen, Jan, Fredrikson, Mats, Hoffmann, Mikael, Spetz Holm, Anna‐Clara
Format: Article
Language:English
Subjects:
Cohort Studies
Early menopause
Endocrine therapy
Estrogen Replacement Therapy
Female
Humans
Malignancy
menopausal hormone therapy
Menopause
Menopause, Premature
Morbidity
Neoplasms
Oophorectomy
Ovariectomy
Population studies
premature menopause
Quality of Life
Retrospective Studies
Surgery
Sweden - epidemiology
Womens health
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Summary:Objective To investigate the use of menopausal hormone therapy (MHT) in premenopausal women after bilateral oophorectomy. Design Retrospective register‐based cohort study. Setting Sweden. Population Swedish women aged 35–44 years without malignancy who underwent bilateral oophorectomy in 2005–2020 were identified using The Swedish National Quality Register of Gynaecological Surgery (GynOp). Methods Data from GynOp were cross‐linked with data on dispensed drugs extracted from the Swedish Prescribed Drug Register. Main outcome measures Proportion of women dispensed MHT at least once within 1 year after surgery. Repeated treatment episodes were defined, and the proportion of ‘person time’ covered by dispensations was analysed. Results In total, 1231 of all women (n = 1706) were dispensed MHT at some point after surgery, with 1177 women dispensed MHT within 1 year. This proportion increased from 64% in 2005 to 84% in 2019 (p 
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.17647