The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study

• Published in: Psychiatry research. Neuroimaging 2024-12, Vol.345, p.111909, Article 111909
• Main Authors: Vessal, Arsalan, Alijanpourotaghsara, Amirreza, Strelnikov, David, Persely, Aliz, Piroska, Marton, Alijanpour, Amirmasoud, Jokkel, Zsofia, Szalontai, Laszlo, Forgo, Bianka, Kozak, Lajos Rudolf, Bekesy-Szabo, Adam, Maurovich-Horvat, Pal, Tarnoki, David Laszlo, Tarnoki, Adam Domonkos
• Format: Article
• Language: English
• Subjects: Adult; Aged; Female; Gene-Environment Interaction; Hippocampus - anatomy & histology; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Limbic Lobe - diagnostic imaging; Limbic system; Magnetic Resonance Imaging; Male; Middle Aged; MRI; Neuroimaging; Twin study; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics
• ISSN: 0925-4927; 1872-7506; 1872-7506
• DOI: 10.1016/j.pscychresns.2024.111909

•MRI twin study on limbic system heritability.•Identified genetic influence on hippocampal morphology.•Environmental factors impact specific limbic regions.•Insights into neurodegenerative and psychiatric disorders.•Novel neuroimaging techniques in genetic research. The limbic system and the hippocampus are complex brain structures with key roles in memory, emotions, sexual stimulation and learning, with subregion abnormalities associated with a range of disorders and psychopathologies. Our study aimed to explore the heritability of specific subfield structures within the limbic system and hippocampus first in a Caucasian twin sample with volBrain pipeline. 59 healthy adult Caucasian twin pairs from the Hungarian Twin Registry without any history of previous neurodegenerative or cerebrovascular diseases underwent brain MRI on a 3.0 T scanner (43 monozygotic, MZ and 16 dizygotic, DZ pairs, with a median age of 50±+27 years). The volBrain automated volumetry pipeline was used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Based on age- and sex-adjusted MZ and DZ intra-pair correlations, the univariate ACE model was applied to calculate additive genetic, shared and unshared environmental influences. Adjusting for age and sex, moderate to strong heritability (A: 59.7 to 73.1 %) was found for most limbic cortex volumes, except for the volumes of entorhinal area and posterior cingulate gyrus where common environmental contribution was detected (C: 56.6 % and 65.0 %, respectively). A substantial heritability (A: 67.0 to 79.4 %) was estimated for the overall hippocampus and most subfield volumes, except for the CA2-CA3 region which was determinated by common environmental factors (C: 45.7 %). Unique environmental variance was a minor to moderate contributor across all variables (E: 20.6 to 54.3 %). Albeit most limbic cortex, overall hippocampus and most subfield volumes are under substantial genetic influence in healthy adult twins, the volumes of entorhinal area, posterior cingulate gyrus and the CA2-CA3 region of the hippocampus are influenced common environmental factors. The findings underline the importance of unique environmental factors which may play a role in the prevention of disorders related to limbic cortex and hippocampus.