Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications

Double cross-linked interpenetrating polymer network (IPN) hydrogels of sodium alginate and gelatin (SA/G) reinforced with 50 wt % cellulose nanocrystals (CNC) have been prepared via the freeze-drying process. The IPNs were designed to incorporate CNC with carboxyl surface groups as a part of the ne...

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Bibliographic Details
Published in:Biomacromolecules 2016-11, Vol.17 (11), p.3714-3723
Main Authors: Naseri, Narges, Deepa, B, Mathew, Aji P, Oksman, Kristiina, Girandon, Lenart
Format: Article
Language:English
Subjects:
Alginates - chemistry
Alginates - pharmacology
Cartilage - drug effects
Cartilage - growth & development
Cell Adhesion - drug effects
Cellulose - chemistry
Cellulose - pharmacology
Dwarfism
Facies
Gelatin - chemistry
Gelatin - pharmacology
Glucuronic Acid - chemistry
Glucuronic Acid - pharmacology
Hexuronic Acids - chemistry
Hexuronic Acids - pharmacology
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology
Microcephaly
Nanoparticles - chemistry
Polymers - chemistry
Polymers - pharmacology
Tensile Strength - drug effects
Tissue Engineering
Trä och bionanokompositer
Wood and Bionanocomposites
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Summary:Double cross-linked interpenetrating polymer network (IPN) hydrogels of sodium alginate and gelatin (SA/G) reinforced with 50 wt % cellulose nanocrystals (CNC) have been prepared via the freeze-drying process. The IPNs were designed to incorporate CNC with carboxyl surface groups as a part of the network contribute to the structural integrity and mechanical stability of the hydrogel. Structural morphology studies of the hydrogels showed a three-dimensional (3D) network of interconnected pores with diameters in the range of 10–192 μm and hierarchical pores with a nanostructured pore wall roughness, which has potential benefits for cell adhesion. Significant improvements in the tensile strength and strain were achieved in 98% RH at 37 °C for CNC cross-linked IPNs. The high porosity of the scaffolds (>93%), high phosphate buffered saline (PBS) uptake, and cytocompatibility toward mesenchymal stem cells (MSCs) are confirmed and considered beneficial for use as a substitute for cartilage.
ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.6b01243