A designated odor-language integration system in the human brain

Odors are surprisingly difficult to name, but the mechanism underlying this phenomenon is poorly understood. In experiments using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the physiological basis of odor naming with a paradigm where olfactory a...

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Bibliographic Details
Published in:The Journal of neuroscience 2014-11, Vol.34 (45), p.14864-14873
Main Authors: Olofsson, Jonas K, Hurley, Robert S, Bowman, Nicholas E, Bao, Xiaojun, Mesulam, M-Marsel, Gottfried, Jay A
Format: Article
Language:English
Subjects:
Adult
Brain Mapping
Cues
Evoked Potentials
Female
functional MRI
human olfactory system
Humans
language
lexical-semantic system
Male
Olfactory Perception
orbitofrontal cortex
Prefrontal Cortex - physiology
Speech
Visual Perception
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Summary:Odors are surprisingly difficult to name, but the mechanism underlying this phenomenon is poorly understood. In experiments using event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), we investigated the physiological basis of odor naming with a paradigm where olfactory and visual object cues were followed by target words that either matched or mismatched the cue. We hypothesized that word processing would not only be affected by its semantic congruency with the preceding cue, but would also depend on the cue modality (olfactory or visual). Performance was slower and less precise when linking a word to its corresponding odor than to its picture. The ERP index of semantic incongruity (N400), reflected in the comparison of nonmatching versus matching target words, was more constrained to posterior electrode sites and lasted longer on odor-cue (vs picture-cue) trials. In parallel, fMRI cross-adaptation in the right orbitofrontal cortex (OFC) and the left anterior temporal lobe (ATL) was observed in response to words when preceded by matching olfactory cues, but not by matching visual cues. Time-series plots demonstrated increased fMRI activity in OFC and ATL at the onset of the odor cue itself, followed by response habituation after processing of a matching (vs nonmatching) target word, suggesting that predictive perceptual representations in these regions are already established before delivery and deliberation of the target word. Together, our findings underscore the modality-specific anatomy and physiology of object identification in the human brain.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.2247-14.2014