A recombinant Bacille Calmette–Guérin construct expressing the Plasmodium falciparum circumsporozoite protein enhances dendritic cell activation and primes for circumsporozoite-specific memory cells in BALB/c mice

Highlights ► BCG-CS induced superior activation of antigen-presenting cells (APCs). ► BCG-CS induced CS-specific antibody responses. ► BCG-CS induced strong CS-specific T-cell responses. ► The response is polarized towards TH1 type immunity. ► BCG-CS is highly efficient in activating APCs for primin...

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Bibliographic Details
Published in:Vaccine 2012-08, Vol.30 (37), p.5578-5584
Main Authors: Arama, Charles, Waseem, Shahid, Fernández, Carmen, Assefaw-Redda, Yohannes, You, Liya, Rodriguez, Ariane, Radošević, Katarina, Goudsmit, Jaap, Kaufmann, Stefan H.E, Reece, Stephen T, Troye-Blomberg, Marita
Format: Article
Language:English
Subjects:
adaptive immunity
Adjuvants, Immunologic - pharmacology
Allergy and Immunology
Animals
Antigen-presenting cells
antigens
B7-1 Antigen - immunology
B7-2 Antigen - immunology
BALB/c mice
Biomarkers - metabolism
CD40 Antigens - immunology
dendritic cells
Dendritic Cells - immunology
Female
immune response
immunization
Immunologic Memory
Interferon-gamma - immunology
interleukin-12
Interleukin-12 - immunology
Interleukin-12 - metabolism
lymph nodes
macrophages
malaria
Malaria Vaccines - administration & dosage
Malaria Vaccines - immunology
Memory cells
Mice
Mice, Inbred BALB C
Mycobacterium bovis
Mycobacterium bovis - genetics
neutralizing antibodies
Phagocytosis - immunology
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - immunology
Plasmodium falciparum circumsporozoite
Protozoan Proteins - genetics
Protozoan Proteins - immunology
Recombinant Bacille Calmette–Guérin
spleen
Spleen - immunology
T-lymphocytes
tumor necrosis factor-alpha
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
Vaccine
vaccines
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
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Summary:Highlights ► BCG-CS induced superior activation of antigen-presenting cells (APCs). ► BCG-CS induced CS-specific antibody responses. ► BCG-CS induced strong CS-specific T-cell responses. ► The response is polarized towards TH1 type immunity. ► BCG-CS is highly efficient in activating APCs for priming of adaptive immunity.
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2011.09.054