Self-Assembling Peptide Nanotubes from Enantiomeric Pairs of Cyclic Peptides with Alternating d and l Amino Acid Residues

Cyclic peptides with alternating d- and l-amino acid residues containing tert-leucine residues in every second position can form peptide nanotubes only when both enantiomers of the peptide are present in the solution. These results strongly indicate the formation of peptide nanotubes that assemble w...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-03, Vol.126 (11), p.3372-3373
Main Authors: Rosenthal-Aizman, Katri, Svensson, Gunnar, Undén, Anders
Format: Article
Language:English
Subjects:
Aminacrine - chemistry
Chemistry
Colloidal state and disperse state
Exact sciences and technology
General and physical chemistry
Miscellaneous
Models, Molecular
Nanotubes, Peptide - chemistry
Neurochemistry with Molecular Neurobiology
neurokemi med molekylär neurobiologi
Peptides, Cyclic - chemistry
Protein Conformation
Stereoisomerism
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Description
Summary:Cyclic peptides with alternating d- and l-amino acid residues containing tert-leucine residues in every second position can form peptide nanotubes only when both enantiomers of the peptide are present in the solution. These results strongly indicate the formation of peptide nanotubes that assemble with one enantiomer in every second position, thereby forming a lamellar structure.
ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/ja0372659