Enantioselective Synthesis of Alcohols and Amines by Iridium-Catalyzed Hydrogenation, Transfer Hydrogenation, and Related Processes

The preparation of chiral alcohols and amines by using iridium catalysis is reviewed. The methods presented include the reduction of ketones or imines by using hydrogen (hydrogenations), isopropanol, formic acid, or formate (transfer hydrogenations). Also dynamic and oxidative kinetic resolutions le...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2013-06, Vol.19 (23), p.7274-7302
Main Authors: Bartoszewicz, Agnieszka, Ahlsten, Nanna, Martín-Matute, Belén
Format: Article
Language:English
Subjects:
Alcohols
Alcohols - chemical synthesis
Alcohols - chemistry
Amines
Amines - chemical synthesis
Amines - chemistry
asymmetric catalysis
Catalysis
Chemistry
Formates
Formates - chemistry
Formic acid
Hydrogenation
Imines - chemistry
Iridium
Iridium - chemistry
Isopropanol
Ketones - chemistry
Molecular Structure
oxidation
Oxidation-Reduction
Reduction
Stereoisomerism
transfer hydrogenation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The preparation of chiral alcohols and amines by using iridium catalysis is reviewed. The methods presented include the reduction of ketones or imines by using hydrogen (hydrogenations), isopropanol, formic acid, or formate (transfer hydrogenations). Also dynamic and oxidative kinetic resolutions leading to chiral alcohols and amines are included. Selected literature reports from early contributions to December 2012 are discussed. Chemical building blocks: Enantiopure alcohols and amines are very important building blocks used in the pharmaceutical, flavors, and fragrances industries. In this review, the preparation of these compounds by using iridium catalysis is discussed. The methods presented include the reduction of ketones or amines by using hydrogen (hydrogenations), isopropanol, formic acid, or formate (transfer hydrogenations; see scheme).
ISSN:0947-6539
1521-3765
1521-3765
DOI:10.1002/chem.201202836