Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium

Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yiel...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-02, Vol.5 (1), p.8278-8278, Article 8278
Main Authors: Jalali, Ali, Amirian, E. Susan, Bainbridge, Matthew N., Armstrong, Georgina N., Liu, Yanhong, Tsavachidis, Spyros, Jhangiani, Shalini N., Plon, Sharon E., Lau, Ching C., Claus, Elizabeth B., Barnholtz-Sloan, Jill S., Il'yasova, Dora, Schildkraut, Joellen, Ali-Osman, Francis, Sadetzki, Siegal, Johansen, Christoffer, Houlston, Richard S., Jenkins, Robert B., Lachance, Daniel, Olson, Sara H., Bernstein, Jonine L., Merrell, Ryan T., Wrensch, Margaret R., Davis, Faith G., Lai, Rose, Shete, Sanjay, Aldape, Kenneth, Amos, Christopher I., Muzny, Donna M., Gibbs, Richard A., Melin, Beatrice S., Bondy, Melissa L.
Format: Article
Language:English
Subjects:
45
631/67/68
692/308/2056
692/699/67/2324
Adult
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain tumors
Chromosome 17
Chromosomes
Chromosomes, Human, Pair 17
Family
Female
Genetic Linkage
Genetic Variation
Glioma
Glioma - genetics
Glioma - pathology
Humanities and Social Sciences
Humans
Male
Middle Aged
multidisciplinary
Mutation
Pedigree
Science
Sequence Analysis, DNA
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (
ISSN:2045-2322
2045-2322
DOI:10.1038/srep08278