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The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease
Visual stimuli are judged for their emotional significance based on two fundamental dimensions, valence and arousal, and may lead to changes in neural and body functions like attention, affect, memory and heart rate. Alterations in behaviour and mood have been encountered in patients with Parkinson&...
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| Published in: | The European journal of neuroscience 2007-08, Vol.26 (3), p.767-774 |
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| Main Authors: | , , , , , , , , , , , , |
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| container_title | The European journal of neuroscience |
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| creator | Brücke, C. Kupsch, A. Schneider, G.-H. Hariz, M.I. Nuttin, B. Kopp, U. Kempf, F. Trottenberg, T. Doyle, L. Chen, C. C. Yarrow, K. Brown, P. Kühn, A. A. |
| description | Visual stimuli are judged for their emotional significance based on two fundamental dimensions, valence and arousal, and may lead to changes in neural and body functions like attention, affect, memory and heart rate. Alterations in behaviour and mood have been encountered in patients with Parkinson's disease (PD) undergoing functional neurosurgery, suggesting that electrical high‐frequency stimulation of the subthalamic nucleus (STN) may interfere with emotional information processing. Here, we use the opportunity to directly record neuronal activity from the STN macroelectrodes in patients with PD during presentation of emotionally laden and neutral pictures taken from the International Affective Picture System (IAPS) to further elucidate the role of the STN in emotional processing. We found a significant event‐related desynchronization of STN alpha activity with pleasant stimuli that correlated with the individual valence rating of the pictures. Our findings suggest involvement of the human STN in valence‐related emotional information processing that can potentially be altered during high‐frequency stimulation of the STN in PD leading to behavioural complications. |
| doi_str_mv | 10.1111/j.1460-9568.2007.05683.x |
| format | article |
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Here, we use the opportunity to directly record neuronal activity from the STN macroelectrodes in patients with PD during presentation of emotionally laden and neutral pictures taken from the International Affective Picture System (IAPS) to further elucidate the role of the STN in emotional processing. We found a significant event‐related desynchronization of STN alpha activity with pleasant stimuli that correlated with the individual valence rating of the pictures. Our findings suggest involvement of the human STN in valence‐related emotional information processing that can potentially be altered during high‐frequency stimulation of the STN in PD leading to behavioural complications.</description><identifier>ISSN: 0953-816X</identifier><identifier>ISSN: 1460-9568</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/j.1460-9568.2007.05683.x</identifier><identifier>PMID: 17686048</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Affective Symptoms - etiology ; Affective Symptoms - physiopathology ; Affective Symptoms/etiology/physiopathology ; Aged ; Alpha Rhythm ; arousal ; basal ganglia ; Electric Stimulation Therapy - adverse effects ; Emotions - physiology ; Evoked Potentials - physiology ; Female ; Humans ; Judgment - physiology ; local field potentials ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; Parkinson Disease - therapy ; Parkinson Disease/physiopathology/psychology/therapy ; Pattern Recognition, Visual - physiology ; Photic Stimulation ; Subthalamic Nucleus - physiopathology ; valence</subject><ispartof>The European journal of neuroscience, 2007-08, Vol.26 (3), p.767-774</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5233-3eff6743f27a3fee3c012d0ad675594a98486e4615f7ee8e9cc8c0503d7b5de73</citedby><cites>FETCH-LOGICAL-c5233-3eff6743f27a3fee3c012d0ad675594a98486e4615f7ee8e9cc8c0503d7b5de73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17686048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10670$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Brücke, C.</creatorcontrib><creatorcontrib>Kupsch, A.</creatorcontrib><creatorcontrib>Schneider, G.-H.</creatorcontrib><creatorcontrib>Hariz, M.I.</creatorcontrib><creatorcontrib>Nuttin, B.</creatorcontrib><creatorcontrib>Kopp, U.</creatorcontrib><creatorcontrib>Kempf, F.</creatorcontrib><creatorcontrib>Trottenberg, T.</creatorcontrib><creatorcontrib>Doyle, L.</creatorcontrib><creatorcontrib>Chen, C. C.</creatorcontrib><creatorcontrib>Yarrow, K.</creatorcontrib><creatorcontrib>Brown, P.</creatorcontrib><creatorcontrib>Kühn, A. A.</creatorcontrib><title>The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Visual stimuli are judged for their emotional significance based on two fundamental dimensions, valence and arousal, and may lead to changes in neural and body functions like attention, affect, memory and heart rate. Alterations in behaviour and mood have been encountered in patients with Parkinson's disease (PD) undergoing functional neurosurgery, suggesting that electrical high‐frequency stimulation of the subthalamic nucleus (STN) may interfere with emotional information processing. Here, we use the opportunity to directly record neuronal activity from the STN macroelectrodes in patients with PD during presentation of emotionally laden and neutral pictures taken from the International Affective Picture System (IAPS) to further elucidate the role of the STN in emotional processing. We found a significant event‐related desynchronization of STN alpha activity with pleasant stimuli that correlated with the individual valence rating of the pictures. Our findings suggest involvement of the human STN in valence‐related emotional information processing that can potentially be altered during high‐frequency stimulation of the STN in PD leading to behavioural complications.</description><subject>Affective Symptoms - etiology</subject><subject>Affective Symptoms - physiopathology</subject><subject>Affective Symptoms/etiology/physiopathology</subject><subject>Aged</subject><subject>Alpha Rhythm</subject><subject>arousal</subject><subject>basal ganglia</subject><subject>Electric Stimulation Therapy - adverse effects</subject><subject>Emotions - physiology</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Judgment - physiology</subject><subject>local field potentials</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson Disease/physiopathology/psychology/therapy</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Photic Stimulation</subject><subject>Subthalamic Nucleus - physiopathology</subject><subject>valence</subject><issn>0953-816X</issn><issn>1460-9568</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkUuP0zAURi0EYsrAX0BewYYEO35mwWIoQwc0GpAoAzvLdW5alzxKnEw7_x5nUpUleOMr-3zX1zoIYUpSGtfbbUq5JEkupE4zQlRKYsXSwyM0O108RjOSC5ZoKn-eoWchbAkhWnLxFJ1RJbUkXM9Qv9wADsOq39jK1t7hDta-bbAP2Lre39keClwMnW_W-M5W0DhIOqgejqFu-8jaCu-61kEII-QbvLO9h6YPeO_7Df5qu1--CW3zOuDCB7ABnqMnpa0CvDju5-j7x8vl_Cq5_rL4NL-4TpzIGEsYlKVUnJWZsqwEYI7QrCC2kEqInNtccy2BSypKBaAhd047Iggr1EoUoNg5ejP1DXvYDSuz63xtu3vTWm8--NsL03ZrM9SDoUQqEvFXEx6_83uA0JvaBwdVZRtoh2CkppwTLv8J0jwOlXEeQT2BrmtD6KA8jUCJGU2arRmFmVGYGU2aB5PmEKMvj28MqxqKv8Gjugi8m4C9r-D-vxuby883YxXzyZT3oYfDKR9tGamYEubHzcLI2_dXSzFfmG_sD2U6vnc</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Brücke, C.</creator><creator>Kupsch, A.</creator><creator>Schneider, G.-H.</creator><creator>Hariz, M.I.</creator><creator>Nuttin, B.</creator><creator>Kopp, U.</creator><creator>Kempf, F.</creator><creator>Trottenberg, T.</creator><creator>Doyle, L.</creator><creator>Chen, C. C.</creator><creator>Yarrow, K.</creator><creator>Brown, P.</creator><creator>Kühn, A. A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope></search><sort><creationdate>200708</creationdate><title>The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease</title><author>Brücke, C. ; Kupsch, A. ; Schneider, G.-H. ; Hariz, M.I. ; Nuttin, B. ; Kopp, U. ; Kempf, F. ; Trottenberg, T. ; Doyle, L. ; Chen, C. C. ; Yarrow, K. ; Brown, P. ; Kühn, A. 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C.</au><au>Yarrow, K.</au><au>Brown, P.</au><au>Kühn, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2007-08</date><risdate>2007</risdate><volume>26</volume><issue>3</issue><spage>767</spage><epage>774</epage><pages>767-774</pages><issn>0953-816X</issn><issn>1460-9568</issn><eissn>1460-9568</eissn><abstract>Visual stimuli are judged for their emotional significance based on two fundamental dimensions, valence and arousal, and may lead to changes in neural and body functions like attention, affect, memory and heart rate. Alterations in behaviour and mood have been encountered in patients with Parkinson's disease (PD) undergoing functional neurosurgery, suggesting that electrical high‐frequency stimulation of the subthalamic nucleus (STN) may interfere with emotional information processing. Here, we use the opportunity to directly record neuronal activity from the STN macroelectrodes in patients with PD during presentation of emotionally laden and neutral pictures taken from the International Affective Picture System (IAPS) to further elucidate the role of the STN in emotional processing. We found a significant event‐related desynchronization of STN alpha activity with pleasant stimuli that correlated with the individual valence rating of the pictures. Our findings suggest involvement of the human STN in valence‐related emotional information processing that can potentially be altered during high‐frequency stimulation of the STN in PD leading to behavioural complications.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17686048</pmid><doi>10.1111/j.1460-9568.2007.05683.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0953-816X |
| ispartof | The European journal of neuroscience, 2007-08, Vol.26 (3), p.767-774 |
| issn | 0953-816X 1460-9568 1460-9568 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Affective Symptoms - etiology Affective Symptoms - physiopathology Affective Symptoms/etiology/physiopathology Aged Alpha Rhythm arousal basal ganglia Electric Stimulation Therapy - adverse effects Emotions - physiology Evoked Potentials - physiology Female Humans Judgment - physiology local field potentials Male Middle Aged Neuropsychological Tests Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson Disease - therapy Parkinson Disease/physiopathology/psychology/therapy Pattern Recognition, Visual - physiology Photic Stimulation Subthalamic Nucleus - physiopathology valence |
| title | The subthalamic region is activated during valence-related emotional processing in patients with Parkinson's disease |
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