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Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma
•Relative and absolute reliability of measures of plasma oxylipins has been investigated.•Relative reliability varied for acceptable to poor.•For linoleic acid-derived oxylipins, abundance in plasma was a contributing issue.•Absolute reliability was poor for all plasma oxylipins investigated. Modern...
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Published in: | Prostaglandins & other lipid mediators 2015-09, Vol.121 (Pt B), p.227-233 |
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description | •Relative and absolute reliability of measures of plasma oxylipins has been investigated.•Relative reliability varied for acceptable to poor.•For linoleic acid-derived oxylipins, abundance in plasma was a contributing issue.•Absolute reliability was poor for all plasma oxylipins investigated.
Modern analytical techniques allow for the measurement of oxylipins derived from linoleic acid in biological samples. Most validatory work has concerned extraction techniques, repeated analysis of aliquots from the same biological sample, and the influence of external factors such as diet and heparin treatment upon their levels, whereas less is known about the relative and absolute reliability of measurements undertaken on different days. A cohort of nineteen healthy males were used, where samples were taken at the same time of day on two occasions, at least 7 days apart. Relative reliability was assessed using Lin’s concordance correlation coefficients (CCC) and intraclass correlation coefficients (ICC). Absolute reliability was assessed by Bland–Altman analyses. Nine linoleic acid oxylipins were investigated. ICC and CCC values ranged from acceptable (0.56 [13-HODE]) to poor (near zero [9(10)- and 12(13)-EpOME]). Bland–Altman limits of agreement were in general quite wide, ranging from ±0.5 (12,13-DiHOME) to ±2 (9(10)-EpOME; log10 scale). It is concluded that relative reliability of linoleic acid-derived oxylipins varies between lipids with compounds such as the HODEs showing better relative reliability than compounds such as the EpOMEs. These differences should be kept in mind when designing and interpreting experiments correlating plasma levels of these lipids with factors such as age, body mass index, rating scales etc. |
doi_str_mv | 10.1016/j.prostaglandins.2015.10.003 |
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Modern analytical techniques allow for the measurement of oxylipins derived from linoleic acid in biological samples. Most validatory work has concerned extraction techniques, repeated analysis of aliquots from the same biological sample, and the influence of external factors such as diet and heparin treatment upon their levels, whereas less is known about the relative and absolute reliability of measurements undertaken on different days. A cohort of nineteen healthy males were used, where samples were taken at the same time of day on two occasions, at least 7 days apart. Relative reliability was assessed using Lin’s concordance correlation coefficients (CCC) and intraclass correlation coefficients (ICC). Absolute reliability was assessed by Bland–Altman analyses. Nine linoleic acid oxylipins were investigated. ICC and CCC values ranged from acceptable (0.56 [13-HODE]) to poor (near zero [9(10)- and 12(13)-EpOME]). Bland–Altman limits of agreement were in general quite wide, ranging from ±0.5 (12,13-DiHOME) to ±2 (9(10)-EpOME; log10 scale). It is concluded that relative reliability of linoleic acid-derived oxylipins varies between lipids with compounds such as the HODEs showing better relative reliability than compounds such as the EpOMEs. These differences should be kept in mind when designing and interpreting experiments correlating plasma levels of these lipids with factors such as age, body mass index, rating scales etc.</description><identifier>ISSN: 1098-8823</identifier><identifier>ISSN: 2212-196X</identifier><identifier>DOI: 10.1016/j.prostaglandins.2015.10.003</identifier><identifier>PMID: 26498702</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Arachidonic acid ; Arachidonic Acids - blood ; Biomarkers - blood ; Bland–Altman analyses ; Calibration ; Chromatography, High Pressure Liquid ; Cohort Studies ; Concordance correlation coefficients ; DiHOME ; HETE ; HODE ; Human plasma ; Humans ; Intraclass correlation coefficients ; Linoleic acid ; Linoleic Acids - blood ; Male ; Oleic Acids - blood ; Oxylipins ; Oxylipins - blood ; Reliability ; Repeatability ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization ; Statistics as Topic ; Tandem Mass Spectrometry ; Young Adult</subject><ispartof>Prostaglandins & other lipid mediators, 2015-09, Vol.121 (Pt B), p.227-233</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-ae220a48b718857ba2db29a14d8cce26bda9dff46713d952e9f77645e5fd3463</citedby><cites>FETCH-LOGICAL-c424t-ae220a48b718857ba2db29a14d8cce26bda9dff46713d952e9f77645e5fd3463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26498702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112032$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Gouveia-Figueira, Sandra</creatorcontrib><creatorcontrib>Bosson, Jenny A.</creatorcontrib><creatorcontrib>Unosson, Jon</creatorcontrib><creatorcontrib>Behndig, Annelie F.</creatorcontrib><creatorcontrib>Nording, Malin L.</creatorcontrib><creatorcontrib>Fowler, Christopher J.</creatorcontrib><title>Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma</title><title>Prostaglandins & other lipid mediators</title><addtitle>Prostaglandins Other Lipid Mediat</addtitle><description>•Relative and absolute reliability of measures of plasma oxylipins has been investigated.•Relative reliability varied for acceptable to poor.•For linoleic acid-derived oxylipins, abundance in plasma was a contributing issue.•Absolute reliability was poor for all plasma oxylipins investigated.
Modern analytical techniques allow for the measurement of oxylipins derived from linoleic acid in biological samples. Most validatory work has concerned extraction techniques, repeated analysis of aliquots from the same biological sample, and the influence of external factors such as diet and heparin treatment upon their levels, whereas less is known about the relative and absolute reliability of measurements undertaken on different days. A cohort of nineteen healthy males were used, where samples were taken at the same time of day on two occasions, at least 7 days apart. Relative reliability was assessed using Lin’s concordance correlation coefficients (CCC) and intraclass correlation coefficients (ICC). Absolute reliability was assessed by Bland–Altman analyses. Nine linoleic acid oxylipins were investigated. ICC and CCC values ranged from acceptable (0.56 [13-HODE]) to poor (near zero [9(10)- and 12(13)-EpOME]). Bland–Altman limits of agreement were in general quite wide, ranging from ±0.5 (12,13-DiHOME) to ±2 (9(10)-EpOME; log10 scale). It is concluded that relative reliability of linoleic acid-derived oxylipins varies between lipids with compounds such as the HODEs showing better relative reliability than compounds such as the EpOMEs. These differences should be kept in mind when designing and interpreting experiments correlating plasma levels of these lipids with factors such as age, body mass index, rating scales etc.</description><subject>Adult</subject><subject>Arachidonic acid</subject><subject>Arachidonic Acids - blood</subject><subject>Biomarkers - blood</subject><subject>Bland–Altman analyses</subject><subject>Calibration</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cohort Studies</subject><subject>Concordance correlation coefficients</subject><subject>DiHOME</subject><subject>HETE</subject><subject>HODE</subject><subject>Human plasma</subject><subject>Humans</subject><subject>Intraclass correlation coefficients</subject><subject>Linoleic acid</subject><subject>Linoleic Acids - blood</subject><subject>Male</subject><subject>Oleic Acids - blood</subject><subject>Oxylipins</subject><subject>Oxylipins - blood</subject><subject>Reliability</subject><subject>Repeatability</subject><subject>Reproducibility of Results</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Statistics as Topic</subject><subject>Tandem Mass Spectrometry</subject><subject>Young Adult</subject><issn>1098-8823</issn><issn>2212-196X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhX0A0VL4C8gHDlyy2I6TOBKXqlBAqoSEKq5mYk_KrJw42Elh_z1ebanEjZMtzffejN5j7LUUOylk-3a_W1LMK9wFmD3NeaeEbMpoJ0T9hJ1L0ZvKGFWfsec574UoYymesTPV6t50Qp2z718xwEr3yIsDhyHHsK3IEwaCgQKtBx5HPiHkLWE-_gPNMSA5Do585TEVsefx9yHQUk7gNPMf2wQzXwLkCV6wpyOEjC8f3gt2e_3h9upTdfPl4-ery5vKaaXXClApAdoMnTSm6QZQflA9SO2Nc6jawUPvx1G3nax93yjsx65rdYPN6Gvd1hesOtnmX7hsg10STZAONgLZ9_Tt0sZ0Z7dps1IqUavCvznxJcCfG-bVTpQdhhIkxi1b2TVSm65p-4K-O6GuZJ0Tjo_mUthjDXZv_63BHms4TksNRf7qYdM2TOgfxX87KMD1CcASzz1hstkRzg49JXSr9ZH-b9MfCQmmJg</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Gouveia-Figueira, Sandra</creator><creator>Bosson, Jenny A.</creator><creator>Unosson, Jon</creator><creator>Behndig, Annelie F.</creator><creator>Nording, Malin L.</creator><creator>Fowler, Christopher J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope></search><sort><creationdate>20150901</creationdate><title>Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma</title><author>Gouveia-Figueira, Sandra ; Bosson, Jenny A. ; Unosson, Jon ; Behndig, Annelie F. ; Nording, Malin L. ; Fowler, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-ae220a48b718857ba2db29a14d8cce26bda9dff46713d952e9f77645e5fd3463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Arachidonic acid</topic><topic>Arachidonic Acids - blood</topic><topic>Biomarkers - blood</topic><topic>Bland–Altman analyses</topic><topic>Calibration</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cohort Studies</topic><topic>Concordance correlation coefficients</topic><topic>DiHOME</topic><topic>HETE</topic><topic>HODE</topic><topic>Human plasma</topic><topic>Humans</topic><topic>Intraclass correlation coefficients</topic><topic>Linoleic acid</topic><topic>Linoleic Acids - blood</topic><topic>Male</topic><topic>Oleic Acids - blood</topic><topic>Oxylipins</topic><topic>Oxylipins - blood</topic><topic>Reliability</topic><topic>Repeatability</topic><topic>Reproducibility of Results</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Statistics as Topic</topic><topic>Tandem Mass Spectrometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gouveia-Figueira, Sandra</creatorcontrib><creatorcontrib>Bosson, Jenny A.</creatorcontrib><creatorcontrib>Unosson, Jon</creatorcontrib><creatorcontrib>Behndig, Annelie F.</creatorcontrib><creatorcontrib>Nording, Malin L.</creatorcontrib><creatorcontrib>Fowler, Christopher J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><jtitle>Prostaglandins & other lipid mediators</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gouveia-Figueira, Sandra</au><au>Bosson, Jenny A.</au><au>Unosson, Jon</au><au>Behndig, Annelie F.</au><au>Nording, Malin L.</au><au>Fowler, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma</atitle><jtitle>Prostaglandins & other lipid mediators</jtitle><addtitle>Prostaglandins Other Lipid Mediat</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>121</volume><issue>Pt B</issue><spage>227</spage><epage>233</epage><pages>227-233</pages><issn>1098-8823</issn><issn>2212-196X</issn><abstract>•Relative and absolute reliability of measures of plasma oxylipins has been investigated.•Relative reliability varied for acceptable to poor.•For linoleic acid-derived oxylipins, abundance in plasma was a contributing issue.•Absolute reliability was poor for all plasma oxylipins investigated.
Modern analytical techniques allow for the measurement of oxylipins derived from linoleic acid in biological samples. Most validatory work has concerned extraction techniques, repeated analysis of aliquots from the same biological sample, and the influence of external factors such as diet and heparin treatment upon their levels, whereas less is known about the relative and absolute reliability of measurements undertaken on different days. A cohort of nineteen healthy males were used, where samples were taken at the same time of day on two occasions, at least 7 days apart. Relative reliability was assessed using Lin’s concordance correlation coefficients (CCC) and intraclass correlation coefficients (ICC). Absolute reliability was assessed by Bland–Altman analyses. Nine linoleic acid oxylipins were investigated. ICC and CCC values ranged from acceptable (0.56 [13-HODE]) to poor (near zero [9(10)- and 12(13)-EpOME]). Bland–Altman limits of agreement were in general quite wide, ranging from ±0.5 (12,13-DiHOME) to ±2 (9(10)-EpOME; log10 scale). It is concluded that relative reliability of linoleic acid-derived oxylipins varies between lipids with compounds such as the HODEs showing better relative reliability than compounds such as the EpOMEs. These differences should be kept in mind when designing and interpreting experiments correlating plasma levels of these lipids with factors such as age, body mass index, rating scales etc.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26498702</pmid><doi>10.1016/j.prostaglandins.2015.10.003</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Arachidonic acid Arachidonic Acids - blood Biomarkers - blood Bland–Altman analyses Calibration Chromatography, High Pressure Liquid Cohort Studies Concordance correlation coefficients DiHOME HETE HODE Human plasma Humans Intraclass correlation coefficients Linoleic acid Linoleic Acids - blood Male Oleic Acids - blood Oxylipins Oxylipins - blood Reliability Repeatability Reproducibility of Results Spectrometry, Mass, Electrospray Ionization Statistics as Topic Tandem Mass Spectrometry Young Adult |
title | Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma |
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