Environmental relevant levels of a benzodiazepine (oxazepam) alters important behavioral traits in a common planktivorous fish, (Rutilus rutilus)

• Published in: Journal of Toxicology and Environmental Health 2017-01, Vol.80 (16-18), p.963-970
• Main Authors: Brodin, Tomas, Nordling, Johanna, Lagesson, Annelie, Klaminder, Jonatan, Hellström, Gustav, Christensen, Bent, Fick, Jerker
• Format: Article
• Language: English
• Subjects: Active control; Animals; Anti-Anxiety Agents - toxicity; Aquatic ecosystems; Aquatic environment; Behavior, Animal - drug effects; Benzodiazepines; Contamination; Cyprinidae - physiology; Drugs; Ecological effects; Ecological risk assessment; Ecology; Effluent treatment; Effluents; Ekologi; Endpoint Determination; Environmental changes; Environmental Exposure - adverse effects; Fish; Fish behavior; Group dynamics; Oxazepam - toxicity; Pharmaceuticals; Risk assessment; Rutilus rutilus; Surface water; Waste Water - chemistry; Wastewater; Wastewater treatment; Water Pollutants, Chemical - toxicity; Water pollution; Waterways
• ISSN: 1528-7394; 1087-2620; 1087-2620; 2381-3504
• DOI: 10.1080/15287394.2017.1352214

Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A complex mix of pharmaceuticals enters waterways via treated wastewater effluent and many remain biochemically active after the drugs reach aquatic systems. However, to date little is known regarding the ecological effects that might arise following pharmaceutical contamination of aquatic environments. One group of particular concern is behaviorally modifying pharmaceuticals as seemingly minor changes in behavior may initiate marked ecological consequences. The aim of this study was to examine the influence of a benzodiazepine anxiolytic drug (oxazepam) on key behavioral traits in wild roach (Rutilus rutilus) at concentrations similar to those encountered in effluent surface waters. Roach exposed to water with high concentrations of oxazepam (280 µg/L) exhibited increased boldness, while roach at low treatment (0.84 µg/L) became bolder and more active compared to control fish. Our results reinforce the notion that anxiolytic drugs may be affecting fish behavior in natural systems, emphasizing the need for further research on ecological impacts of pharmaceuticals in aquatic systems and development of new tools to incorporate ecologically relevant behavioral endpoints into ecotoxicological risk assessment.