Cross-Neutralization of Hantaviruses with Immune Sera from Experimentally Infected Animals and from Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome Patients

Plaque-reduction neutralization tests were done with eight of nine known representative hantaviruses and immune sera from experimentally infected animals and from patients with hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Results obtained with animal sera demo...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1995-12, Vol.172 (6), p.1581-1584
Main Authors: Chu, Yong-Kyu, Jennings, Gerald, Schmaljohn, Alan, Elgh, Fredrik, Hjelle, Brian, Lee, Ho-Wang, Jenison, Steven, Ksiazek, Thomas, Peters, C. J., Rollin, Pierre, Schmaljohn, Connie
Format: Article
Language:English
Subjects:
Animals
Antibodies
Biological and medical sciences
Cell culture techniques
Concise Communications
Cross Reactions
Hantaan virus - immunology
Hantavirus
Hantavirus pulmonary syndrome
Hemorrhagic fever with renal syndrome
Hemorrhagic Fever with Renal Syndrome - immunology
Human viral diseases
Humans
Immune Sera - immunology
Infectious diseases
Lung diseases
Medical genetics
Medical sciences
Mice
Miscellaneous
Neutralization Tests
Rabbits
Rats
Respiratory Distress Syndrome, Adult - immunology
Viral diseases
Virology
Viruses
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plaque-reduction neutralization tests were done with eight of nine known representative hantaviruses and immune sera from experimentally infected animals and from patients with hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Results obtained with animal sera demonstrated each virus to be antigenically unique. Neutralization with the HPS patient sera was highest with Sin Nombre (SN) virus and to a lesser extent with Black Creek Canal (BCC) virus. Sera from Korean HFRS patients reacted best with Hantaan virus, but cross-reactivity with all other viruses except Thottapalayam (TPM) virus was also observed. Sera from Swedish HFRS patients reacted best with Puumala virus but cross-reacted with Prospect Hill, SN, and BCC viruses and to a lesser extent with all of the other viruses except TPM virus.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/172.6.1581