Inflammatory markers in bronchoalveolar lavage fluid from human volunteers 2 hours after hydrogen fluoride exposure

Fluoride has been in focus as a possible causal agent for respiratory symptoms amongst aluminium potroom workers for several decades. Previously, using bronchoalveolar lavage (BAL), we demonstrated airway inflammation in healthy volunteers 24 hours after exposure to hydrogen fluoride (HF). The objec...

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Bibliographic Details
Published in:Human & experimental toxicology 2005-03, Vol.24 (3), p.101-108
Main Authors: Lund, K, Dunster, C, Ramis, I, Sandstrom, T, Kelly, F J, SøStrand, P, Schwarze, P, Skovlund, E, Boe, J, Kongerud, J, Refsnes, M
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Air Pollutants, Occupational - toxicity
Antioxidants
Antioxidants - analysis
Asthma
Biological and medical sciences
Biological Markers/analysis
Biomarkers - analysis
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology
Cell Count
Chemical and industrial products toxicology. Toxic occupational diseases
Fluorides
Health care
Hospitals
Humans
Hydrofluoric Acid - toxicity
Hydrogen
Lavage
Male
Medical sciences
Neutrophils
Pneumonia - chemically induced
Pneumonia - immunology
Pneumonia/chemically induced/immunology
Toxicology
Tumor necrosis factor-TNF
Various organic compounds
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Summary:Fluoride has been in focus as a possible causal agent for respiratory symptoms amongst aluminium potroom workers for several decades. Previously, using bronchoalveolar lavage (BAL), we demonstrated airway inflammation in healthy volunteers 24 hours after exposure to hydrogen fluoride (HF). The objective of the present study was to examine early lung responses to HF exposure. Bronchoscopy with BAL was performed 2 hours after the end of 1-hour exposure to HF. Significant reductions in the total cell number and the number of neutrophils and lymphocytes were observed in bronchoalveolar portion (BAP), whereas there were no significant changes in the bronchial portion (BP). Significantly decreased concentrations of b2-MG, IL-6 and total protein were found in both BAP and BP. Additionally, IL-8 was significantly reduced in BP, and ICAM-1 and albumin were present in lower concentrations in BAP. Lung function measurements were not affected by HF exposure. These reported effects are presumably transitory, as many were not present in the airways 24 hours after a similar HF exposure.
ISSN:0960-3271
1477-0903
DOI:10.1191/0960327104ht506oa