Oxylipins in cerebrospinal fluid in clinically isolated syndrome and relapsing remitting multiple sclerosis

• Published in: Prostaglandins & other lipid mediators 2018-09, Vol.138, p.41-47
• Main Authors: Håkansson, Irene, Gouveia-Figueira, Sandra, Ernerudh, Jan, Vrethem, Magnus, Ghafouri, Nazdar, Ghafouri, Bijar, Nording, Malin
• Format: Article
• Language: English
• Subjects: Clinically isolated ndrome; Clinically isolated syndrome; Hydroxyoctadecadienoic acid; Mass spectrometry; Multiple sclerosis; Oxylipins
• ISSN: 1098-8823; 2212-196X
• DOI: 10.1016/j.prostaglandins.2018.08.003

•Oxylipin levels in CSF from 41 patients with CIS or RRMS and 22 controls are given.•CSF levels of 9-HODE and 13-HODE were significantly increased in patients.•Oxylipin levels were not associated with disease activity during follow-up. Although oxylipins are involved in inflammation, data on these lipid mediators in multiple sclerosis are sparse. In this study, a panel of oxylipins were analysed swith liquid chromatography tandem mass spectrometry in cerebrospinal fluid (CSF) from 41 treatment naïve patients with clinically isolated syndrome (CIS) or relapsing remitting MS (RRMS) and 22 healthy controls. CSF levels of 9-hydroxyoctadecadienoic acid (9-HODE) and 13-hydroxyoctadecadienoic acid (13-HODE) were significantly higher in patients than in healthy controls (9-HODE median 380 nM (interquartile range 330–450 nM) in patients and 290 nM (interquartile range 250–340 nM) in controls, 13-HODE median 930 nM (interquartile range 810–1080 nM) in patients and 690 nM (interquartile range 570–760 nM) in controls, p