The type II secretion system – a dynamic fiber assembly nanomachine

Type II secretion systems (T2SSs) share common origins and structure with archaeal flagella (archaella) and pili, bacterial competence systems and type IV pili. All of these systems use a conserved ATP-powered machinery to assemble helical fibers that are anchored in the plasma membrane. The T2SSs a...

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Bibliographic Details
Published in:Research in microbiology 2013-07, Vol.164 (6), p.545-555
Main Authors: Campos, Manuel, Cisneros, David A., Nivaskumar, Mangayarkarasi, Francetic, Olivera
Format: Article
Language:English
Subjects:
Bacteria - genetics
Bacteria - metabolism
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacterial Secretion Systems
Bacteriology
Biochemistry, Molecular Biology
Cell Membrane - genetics
Cell Membrane - metabolism
Fimbriae, Bacterial - genetics
Fimbriae, Bacterial - metabolism
Life Sciences
Microbiology and Parasitology
Molecular biology
Pilus assembly
Protein Transport
Pseudopilins
Structural Biology
Type II protein secretion
Type IV pili
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Summary:Type II secretion systems (T2SSs) share common origins and structure with archaeal flagella (archaella) and pili, bacterial competence systems and type IV pili. All of these systems use a conserved ATP-powered machinery to assemble helical fibers that are anchored in the plasma membrane. The T2SSs assemble pseudopili, periplasmic filaments that promote extracellular secretion of folded periplasmic proteins. Comparative analysis of T2SSs and related fiber assembly nanomachines might provide important clues on their functional specificities and dynamics. This review focuses on recent developments in the study of pseudopilus structure and biogenesis, and discusses mechanistic models of pseudopilus function in protein secretion.
ISSN:0923-2508
1769-7123
1769-7123
0923-2508
DOI:10.1016/j.resmic.2013.03.013