Leptin predicts the development of diabetes in Mauritian men, but not women: a population-based study

• Published in: Int J Obes (Lond) 2007-07, Vol.31 (7), p.1126-1133
• Main Authors: Söderberg, S, Zimmet, P, Tuomilehto, J, Chitson, P, Gareeboo, H, Alberti, K.G.M.M, Shaw, J.E
• Format: Article
• Language: English
• Subjects: Adipocytes; Adult; Aged; Biological and medical sciences; biomarkers; Blood pressure; Body mass index; Cardiology; Clinical medicine; cohort studies; Comparative analysis; Data Collection; Demographic aspects; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - ethnology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiological studies; Epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; gender differences; Glucose; Health aspects; Health Promotion and Disease Prevention; Humans; Incidence; Insulin; Insulin resistance; Internal Medicine; Leptin; Leptin - blood; Male; Mauritanians; Mauritius - epidemiology; Medical sciences; Medicine; Medicine & Public Health; men; Metabolic Diseases; Metabolism; Middle Aged; Minority & ethnic groups; Obesity; original-article; Physiological aspects; Population studies; prediction; Predictive Value of Tests; Prevention; Public Health; Risk Factors; Sex Distribution; Surveys and Questionnaires; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Women
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0803561

Objective: To determine if levels of the adipocyte-derived hormone, leptin, predict the development of type 2 diabetes. Methods: Population-based surveys were undertaken in the multiethnic nation of Mauritius in 1987, 1992 and 1998. Questionnaires, anthropometric measurements, and a 2-h 75-g oral glucose tolerance test were included. A cohort of 2330 participants who were free of diabetes, aged 25-79 years in 1987, and who were followed-up in 1992 and 1998 was studied. Serum leptin was measured in baseline samples. Glucose tolerance was classified according to WHO (World Health Organization) 1999 criteria. Results: In total, 456 subjects developed diabetes over 11 years with similar incidences in all ethnic groups (P=0.2). Baseline leptin correlated positively with anthropometric measurements, fasting and postload insulin and homeostasis model assessment indices (all P