Bioresorbable films of polycaprolactone blended with poly(lactic acid) or poly(lactic-co-glycolic acid)

Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-09, Vol.248, p.126654-126654, Article 126654
Main Authors: Dodda, Jagan Mohan, Azar, Mina Ghafouri, Bělský, Petr, Šlouf, Miroslav, Gajdošová, Veronika, Kasi, Phanindra Babu, Anerillas, Luis Oliveros, Kovářík, Tomáš
Format: Article
Language:English
Subjects:
Biocompatibility
Mechanical properties
Nanoscale morphology
Polycaprolactone
Resorbable blends
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Summary:Recent complications on the use of polypropylene meshes for hernia repair has led to the development of meshes or films, which were based on resorbable polymers such as polycaprolactone (PCL), polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These materials are able to create suitable bioactive environment for the growth and development of cells. In this research, we mainly focused on the relations among structure, mechanical performance and biocompatiblity of PCL/PLA and PCL/PLGA and blends prepared by solution casting. The films were characterized regarding the chemical structure, morphology, physicochemical properties, cytotoxicity, biocompatibility and cell growth. All the films showed high tensile strength ranging from 9.5 to 11.8 MPa. SAXS showed that the lamellar stack structure typical for PCL was present even in the blend films while the morphological parameters of the stacks varied slightly with the content of PLGA or PLA in the blends. WAXS indicated preferential orientation of crystallites (and thus, also the lamellar stacks) in the blend films. In vitro studies revealed that PCL/PLGA films displayed better cell adhesion, spreading and proliferation than PCL/PLA and PCL films. Further the effect of blending on the degradation was investigated, to understand the significant variable within the process that could provide further control of cell adhesion. The results showed that the investigated blend films are promising materials for biomedical applications.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2023.126654