A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia

A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%–4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the trans...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2004, Vol.148 (1), p.77-79
Main Authors: Lazarevic̀, Vladimir Lj, Tomin, Dragica, Jankovic̀, Gradimir M., Antic̀, Darko, Denčic̀, Marija, Gotic, Mirjana, Boškovic̀, Darinka
Format: Article
Language:English
Subjects:
Aged
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 2
Humans
Leukemia, Myeloid, Acute - etiology
Leukemia, Myeloid, Acute - genetics
Male
Thrombocythemia, Essential - complications
Thrombocythemia, Essential - drug therapy
Translocation, Genetic
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Summary:A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%–4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
ISSN:0165-4608
1873-4456
1873-4456
DOI:10.1016/S0165-4608(03)00215-2