Interfering with Cancer: A Brief Outline of Advances in RNA Interference in Oncology

RNA interference (RNAi) is a potent and ubiquitous gene-silencing mechanism that is generating considerable excitement in the fields of molecular biology and gene therapy. It is now in widespread use for loss-of-function analysis in many diseases including cancer. Nevertheless, RNAi is still in its...

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Bibliographic Details
Published in:Tumor biology 2004-09, Vol.25 (5-6), p.329-336
Main Authors: Rye, P.D., Stigbrand, T.
Format: Article
Language:English
Subjects:
Genetic Therapy
Humans
Medical Oncology - trends
Molecular oncology
Neoplasms - genetics
Neoplasms - therapy
Research Commentary
RNA Interference
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Summary:RNA interference (RNAi) is a potent and ubiquitous gene-silencing mechanism that is generating considerable excitement in the fields of molecular biology and gene therapy. It is now in widespread use for loss-of-function analysis in many diseases including cancer. Nevertheless, RNAi is still in its infancy, with new discoveries appearing on a monthly basis. This article presents a brief outline of the history and recent advances in RNAi with a specific focus on its potential in oncology.
ISSN:1010-4283
1423-0380
1423-0380
DOI:10.1159/000081403