Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, sho...

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Bibliographic Details
Published in:British journal of cancer 2009-05, Vol.100 (10), p.1603-1607
Main Authors: Nilsson, J, Skog, J, Nordstrand, A, Baranov, V, Mincheva-Nilsson, L, Breakefield, X O, Widmark, A
Format: Article
Language:English
Subjects:
Androgens
Antigens
Antigens, Neoplasm - analysis
Antigens, Neoplasm - genetics
Antigens, Neoplasm - urine
Biological and medical sciences
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - urine
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Drug Resistance
Epidemiology
Exosomes - genetics
Exosomes - pathology
Humans
Male
Medical research
Medical sciences
Metastasis
MicroRNAs
Microscopy
Molecular Medicine
Nephrology. Urinary tract diseases
Neurosurgery
Oncogene Proteins, Fusion - analysis
Oncogene Proteins, Fusion - genetics
Oncogene Proteins, Fusion - urine
Oncology
Prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Prostatic Neoplasms - urine
RNA, Messenger - analysis
Short Communication
Tumors
Tumors of the urinary system
Urinalysis - methods
Urinary tract. Prostate gland
Urine
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Description
Summary:Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/sj.bjc.6605058