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Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could...

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Published in:International journal of cancer 2010-09, Vol.127 (6), p.1421-1428
Main Authors: Jacobs, Eric J., Chanock, Stephen J., Fuchs, Charles S., LaCroix, Andrea, McWilliams, Robert R., Steplowski, Emily, Stolzenberg‐Solomon, Rachael Z., Arslan, Alan A., Bueno‐de‐Mesquita, H. Bas, Gross, Myron, Helzlsouer, Kathy, Petersen, Gloria, Zheng, Wei, Agalliu, Ilir, Allen, Naomi E., Amundadottir, Laufey, Boutron‐Ruault, Marie‐Christine, Buring, Julie E., Canzian, Federico, Clipp, Sandra, Dorronsoro, Miren, Gaziano, J. Michael, Giovannucci, Edward L., Hankinson, Susan E., Hartge, Patricia, Hoover, Robert N., Hunter, David J., Jacobs, Kevin B., Jenab, Mazda, Kraft, Peter, Kooperberg, Charles, Lynch, Shannon M., Sund, Malin, Mendelsohn, Julie B., Mouw, Tracy, Newton, Christina C., Overvad, Kim, Palli, Domenico, Peeters, Petra H.M., Rajkovic, Aleksandar, Shu, Xiao‐Ou, Thomas, Gilles, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Virtamo, Jarmo, Wactawski‐Wende, Jean, Wolpin, Brian M., Yu, Kai, Zeleniuch‐Jacquotte, Anne
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cited_by cdi_FETCH-LOGICAL-c5178-65e13c46f7af40bd1af83319081e98251399cd55dc9a06a187cd8269d9e3f3fa3
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container_end_page 1428
container_issue 6
container_start_page 1421
container_title International journal of cancer
container_volume 127
creator Jacobs, Eric J.
Chanock, Stephen J.
Fuchs, Charles S.
LaCroix, Andrea
McWilliams, Robert R.
Steplowski, Emily
Stolzenberg‐Solomon, Rachael Z.
Arslan, Alan A.
Bueno‐de‐Mesquita, H. Bas
Gross, Myron
Helzlsouer, Kathy
Petersen, Gloria
Zheng, Wei
Agalliu, Ilir
Allen, Naomi E.
Amundadottir, Laufey
Boutron‐Ruault, Marie‐Christine
Buring, Julie E.
Canzian, Federico
Clipp, Sandra
Dorronsoro, Miren
Gaziano, J. Michael
Giovannucci, Edward L.
Hankinson, Susan E.
Hartge, Patricia
Hoover, Robert N.
Hunter, David J.
Jacobs, Kevin B.
Jenab, Mazda
Kraft, Peter
Kooperberg, Charles
Lynch, Shannon M.
Sund, Malin
Mendelsohn, Julie B.
Mouw, Tracy
Newton, Christina C.
Overvad, Kim
Palli, Domenico
Peeters, Petra H.M.
Rajkovic, Aleksandar
Shu, Xiao‐Ou
Thomas, Gilles
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
Virtamo, Jarmo
Wactawski‐Wende, Jean
Wolpin, Brian M.
Yu, Kai
Zeleniuch‐Jacquotte, Anne
description A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
doi_str_mv 10.1002/ijc.25148
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A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). 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A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). 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Bas</au><au>Gross, Myron</au><au>Helzlsouer, Kathy</au><au>Petersen, Gloria</au><au>Zheng, Wei</au><au>Agalliu, Ilir</au><au>Allen, Naomi E.</au><au>Amundadottir, Laufey</au><au>Boutron‐Ruault, Marie‐Christine</au><au>Buring, Julie E.</au><au>Canzian, Federico</au><au>Clipp, Sandra</au><au>Dorronsoro, Miren</au><au>Gaziano, J. Michael</au><au>Giovannucci, Edward L.</au><au>Hankinson, Susan E.</au><au>Hartge, Patricia</au><au>Hoover, Robert N.</au><au>Hunter, David J.</au><au>Jacobs, Kevin B.</au><au>Jenab, Mazda</au><au>Kraft, Peter</au><au>Kooperberg, Charles</au><au>Lynch, Shannon M.</au><au>Sund, Malin</au><au>Mendelsohn, Julie B.</au><au>Mouw, Tracy</au><au>Newton, Christina C.</au><au>Overvad, Kim</au><au>Palli, Domenico</au><au>Peeters, Petra H.M.</au><au>Rajkovic, Aleksandar</au><au>Shu, Xiao‐Ou</au><au>Thomas, Gilles</au><au>Tobias, Geoffrey S.</au><au>Trichopoulos, Dimitrios</au><au>Virtamo, Jarmo</au><au>Wactawski‐Wende, Jean</au><au>Wolpin, Brian M.</au><au>Yu, Kai</au><au>Zeleniuch‐Jacquotte, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>127</volume><issue>6</issue><spage>1421</spage><epage>1428</epage><pages>1421-1428</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20049842</pmid><doi>10.1002/ijc.25148</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0020-7136
ispartof International journal of cancer, 2010-09, Vol.127 (6), p.1421-1428
issn 0020-7136
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language eng
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source Wiley-Blackwell Read & Publish Collection
subjects Case-Control Studies
Cohort Studies
epidemiology
Family history
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
MEDICIN
MEDICINE
pancreatic cancer
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - genetics
title Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
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