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Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could...
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Published in: | International journal of cancer 2010-09, Vol.127 (6), p.1421-1428 |
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container_title | International journal of cancer |
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creator | Jacobs, Eric J. Chanock, Stephen J. Fuchs, Charles S. LaCroix, Andrea McWilliams, Robert R. Steplowski, Emily Stolzenberg‐Solomon, Rachael Z. Arslan, Alan A. Bueno‐de‐Mesquita, H. Bas Gross, Myron Helzlsouer, Kathy Petersen, Gloria Zheng, Wei Agalliu, Ilir Allen, Naomi E. Amundadottir, Laufey Boutron‐Ruault, Marie‐Christine Buring, Julie E. Canzian, Federico Clipp, Sandra Dorronsoro, Miren Gaziano, J. Michael Giovannucci, Edward L. Hankinson, Susan E. Hartge, Patricia Hoover, Robert N. Hunter, David J. Jacobs, Kevin B. Jenab, Mazda Kraft, Peter Kooperberg, Charles Lynch, Shannon M. Sund, Malin Mendelsohn, Julie B. Mouw, Tracy Newton, Christina C. Overvad, Kim Palli, Domenico Peeters, Petra H.M. Rajkovic, Aleksandar Shu, Xiao‐Ou Thomas, Gilles Tobias, Geoffrey S. Trichopoulos, Dimitrios Virtamo, Jarmo Wactawski‐Wende, Jean Wolpin, Brian M. Yu, Kai Zeleniuch‐Jacquotte, Anne |
description | A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study. |
doi_str_mv | 10.1002/ijc.25148 |
format | article |
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Bas ; Gross, Myron ; Helzlsouer, Kathy ; Petersen, Gloria ; Zheng, Wei ; Agalliu, Ilir ; Allen, Naomi E. ; Amundadottir, Laufey ; Boutron‐Ruault, Marie‐Christine ; Buring, Julie E. ; Canzian, Federico ; Clipp, Sandra ; Dorronsoro, Miren ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Hankinson, Susan E. ; Hartge, Patricia ; Hoover, Robert N. ; Hunter, David J. ; Jacobs, Kevin B. ; Jenab, Mazda ; Kraft, Peter ; Kooperberg, Charles ; Lynch, Shannon M. ; Sund, Malin ; Mendelsohn, Julie B. ; Mouw, Tracy ; Newton, Christina C. ; Overvad, Kim ; Palli, Domenico ; Peeters, Petra H.M. ; Rajkovic, Aleksandar ; Shu, Xiao‐Ou ; Thomas, Gilles ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Virtamo, Jarmo ; Wactawski‐Wende, Jean ; Wolpin, Brian M. ; Yu, Kai ; Zeleniuch‐Jacquotte, Anne</creator><creatorcontrib>Jacobs, Eric J. ; Chanock, Stephen J. ; Fuchs, Charles S. ; LaCroix, Andrea ; McWilliams, Robert R. ; Steplowski, Emily ; Stolzenberg‐Solomon, Rachael Z. ; Arslan, Alan A. ; Bueno‐de‐Mesquita, H. Bas ; Gross, Myron ; Helzlsouer, Kathy ; Petersen, Gloria ; Zheng, Wei ; Agalliu, Ilir ; Allen, Naomi E. ; Amundadottir, Laufey ; Boutron‐Ruault, Marie‐Christine ; Buring, Julie E. ; Canzian, Federico ; Clipp, Sandra ; Dorronsoro, Miren ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Hankinson, Susan E. ; Hartge, Patricia ; Hoover, Robert N. ; Hunter, David J. ; Jacobs, Kevin B. ; Jenab, Mazda ; Kraft, Peter ; Kooperberg, Charles ; Lynch, Shannon M. ; Sund, Malin ; Mendelsohn, Julie B. ; Mouw, Tracy ; Newton, Christina C. ; Overvad, Kim ; Palli, Domenico ; Peeters, Petra H.M. ; Rajkovic, Aleksandar ; Shu, Xiao‐Ou ; Thomas, Gilles ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Virtamo, Jarmo ; Wactawski‐Wende, Jean ; Wolpin, Brian M. ; Yu, Kai ; Zeleniuch‐Jacquotte, Anne</creatorcontrib><description>A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.25148</identifier><identifier>PMID: 20049842</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Case-Control Studies ; Cohort Studies ; epidemiology ; Family history ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; MEDICIN ; MEDICINE ; pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - genetics</subject><ispartof>International journal of cancer, 2010-09, Vol.127 (6), p.1421-1428</ispartof><rights>Copyright © 2010 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5178-65e13c46f7af40bd1af83319081e98251399cd55dc9a06a187cd8269d9e3f3fa3</citedby><cites>FETCH-LOGICAL-c5178-65e13c46f7af40bd1af83319081e98251399cd55dc9a06a187cd8269d9e3f3fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20049842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33782$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobs, Eric J.</creatorcontrib><creatorcontrib>Chanock, Stephen J.</creatorcontrib><creatorcontrib>Fuchs, Charles S.</creatorcontrib><creatorcontrib>LaCroix, Andrea</creatorcontrib><creatorcontrib>McWilliams, Robert R.</creatorcontrib><creatorcontrib>Steplowski, Emily</creatorcontrib><creatorcontrib>Stolzenberg‐Solomon, Rachael Z.</creatorcontrib><creatorcontrib>Arslan, Alan A.</creatorcontrib><creatorcontrib>Bueno‐de‐Mesquita, H. Bas</creatorcontrib><creatorcontrib>Gross, Myron</creatorcontrib><creatorcontrib>Helzlsouer, Kathy</creatorcontrib><creatorcontrib>Petersen, Gloria</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Agalliu, Ilir</creatorcontrib><creatorcontrib>Allen, Naomi E.</creatorcontrib><creatorcontrib>Amundadottir, Laufey</creatorcontrib><creatorcontrib>Boutron‐Ruault, Marie‐Christine</creatorcontrib><creatorcontrib>Buring, Julie E.</creatorcontrib><creatorcontrib>Canzian, Federico</creatorcontrib><creatorcontrib>Clipp, Sandra</creatorcontrib><creatorcontrib>Dorronsoro, Miren</creatorcontrib><creatorcontrib>Gaziano, J. Michael</creatorcontrib><creatorcontrib>Giovannucci, Edward L.</creatorcontrib><creatorcontrib>Hankinson, Susan E.</creatorcontrib><creatorcontrib>Hartge, Patricia</creatorcontrib><creatorcontrib>Hoover, Robert N.</creatorcontrib><creatorcontrib>Hunter, David J.</creatorcontrib><creatorcontrib>Jacobs, Kevin B.</creatorcontrib><creatorcontrib>Jenab, Mazda</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Kooperberg, Charles</creatorcontrib><creatorcontrib>Lynch, Shannon M.</creatorcontrib><creatorcontrib>Sund, Malin</creatorcontrib><creatorcontrib>Mendelsohn, Julie B.</creatorcontrib><creatorcontrib>Mouw, Tracy</creatorcontrib><creatorcontrib>Newton, Christina C.</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Peeters, Petra H.M.</creatorcontrib><creatorcontrib>Rajkovic, Aleksandar</creatorcontrib><creatorcontrib>Shu, Xiao‐Ou</creatorcontrib><creatorcontrib>Thomas, Gilles</creatorcontrib><creatorcontrib>Tobias, Geoffrey S.</creatorcontrib><creatorcontrib>Trichopoulos, Dimitrios</creatorcontrib><creatorcontrib>Virtamo, Jarmo</creatorcontrib><creatorcontrib>Wactawski‐Wende, Jean</creatorcontrib><creatorcontrib>Wolpin, Brian M.</creatorcontrib><creatorcontrib>Yu, Kai</creatorcontrib><creatorcontrib>Zeleniuch‐Jacquotte, Anne</creatorcontrib><title>Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.</description><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>epidemiology</subject><subject>Family history</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - genetics</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi1ERZeFQ_9A5RusRLbjOB92D0irlNKiSiABvVquY3fdJvFiJ61y46fjJUs_DpxGmnn8zFgvQgcElgQgPbI3apnmJGMv0IwALxNISf4SzeIMkpLQYh-9DuEGgJAcsldoPwXIOMvSGfp9KlvbjHhtQ-_8iJ3BSnZKeyy7GnsbbretTWx5LXurdtNjvMIb5xpdR042Y7ABG-9a3K81_vZIV5Orcmvn-1i6EKsdWvw-Qt-ja_EG7RnZBP12V-fo5-mnH9VZcvH183m1ukhUTkqWFLkmVGWFKaXJ4Kom0jBKCQdGNGfx85RzVed5rbiEQhJWqpqlBa-5poYaSefow-QN93ozXImNt630o3DSihN7uRLOX4uhHQSlJUsj_nHCI9vqWumu97J59ur5pLNrce3uRMrjVsqj4N1O4N2vQYdetDYo3TSy024IoqQZUGDZllxMpPIuBK_NwxYCYpuviPmKv_lG9vDpWQ_kv0AjcDQB97bR4_9N4vxLNSn_AAEssUE</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Jacobs, Eric J.</creator><creator>Chanock, Stephen J.</creator><creator>Fuchs, Charles S.</creator><creator>LaCroix, Andrea</creator><creator>McWilliams, Robert R.</creator><creator>Steplowski, Emily</creator><creator>Stolzenberg‐Solomon, Rachael Z.</creator><creator>Arslan, Alan A.</creator><creator>Bueno‐de‐Mesquita, H. 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Bas</au><au>Gross, Myron</au><au>Helzlsouer, Kathy</au><au>Petersen, Gloria</au><au>Zheng, Wei</au><au>Agalliu, Ilir</au><au>Allen, Naomi E.</au><au>Amundadottir, Laufey</au><au>Boutron‐Ruault, Marie‐Christine</au><au>Buring, Julie E.</au><au>Canzian, Federico</au><au>Clipp, Sandra</au><au>Dorronsoro, Miren</au><au>Gaziano, J. Michael</au><au>Giovannucci, Edward L.</au><au>Hankinson, Susan E.</au><au>Hartge, Patricia</au><au>Hoover, Robert N.</au><au>Hunter, David J.</au><au>Jacobs, Kevin B.</au><au>Jenab, Mazda</au><au>Kraft, Peter</au><au>Kooperberg, Charles</au><au>Lynch, Shannon M.</au><au>Sund, Malin</au><au>Mendelsohn, Julie B.</au><au>Mouw, Tracy</au><au>Newton, Christina C.</au><au>Overvad, Kim</au><au>Palli, Domenico</au><au>Peeters, Petra H.M.</au><au>Rajkovic, Aleksandar</au><au>Shu, Xiao‐Ou</au><au>Thomas, Gilles</au><au>Tobias, Geoffrey S.</au><au>Trichopoulos, Dimitrios</au><au>Virtamo, Jarmo</au><au>Wactawski‐Wende, Jean</au><au>Wolpin, Brian M.</au><au>Yu, Kai</au><au>Zeleniuch‐Jacquotte, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>127</volume><issue>6</issue><spage>1421</spage><epage>1428</epage><pages>1421-1428</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20049842</pmid><doi>10.1002/ijc.25148</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0020-7136 |
ispartof | International journal of cancer, 2010-09, Vol.127 (6), p.1421-1428 |
issn | 0020-7136 1097-0215 1097-0215 |
language | eng |
recordid | cdi_swepub_primary_oai_DiVA_org_umu_33782 |
source | Wiley-Blackwell Read & Publish Collection |
subjects | Case-Control Studies Cohort Studies epidemiology Family history Genetic Predisposition to Disease Genome-Wide Association Study Humans MEDICIN MEDICINE pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics |
title | Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan) |
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