Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy

Background  Gastrointestinal (GI) complications are common in hereditary transthyretin amyloidosis and an autonomic dysfunction has been considered to explain these symptoms. The aim of this study was to investigate the impact of autonomic neuropathy on gastric emptying in hereditary transthyretin a...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2012-12, Vol.24 (12), p.1111-e568
Main Authors: Wixner, J., Karling, P., Rydh, A., Hörnsten, R., Wiklund, U., Anan, I., Suhr, O. B.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Amyloid Neuropathies, Familial - complications
Amyloid Neuropathies, Familial - diagnostic imaging
Amyloid Neuropathies, Familial - physiopathology
Amyloidosis
Autonomic nervous system
Autonomic Nervous System Diseases - diagnostic imaging
Autonomic Nervous System Diseases - etiology
Autonomic Nervous System Diseases - physiopathology
autonomic nervous system disorders
Body mass index
Cardiovascular system
Female
Gastric emptying
Gastric Emptying - physiology
Heart rate
hereditary
Humans
Male
Middle Aged
Neuropathy
nutrition status
Nutritional status
Original
Parasympathetic nervous system
Radionuclide Imaging
Regression analysis
Scintigraphy
transthyretin
Young Adult
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Summary:Background  Gastrointestinal (GI) complications are common in hereditary transthyretin amyloidosis and an autonomic dysfunction has been considered to explain these symptoms. The aim of this study was to investigate the impact of autonomic neuropathy on gastric emptying in hereditary transthyretin amyloidosis and to relate these findings to nutritional status, GI symptoms, gender, and age at disease onset. Methods  Gastric emptying was evaluated with gastric emptying scintigraphy. Spectral analysis of the heart rate variability and cardiovascular responses after tilt test were used to assess the autonomic function. The nutritional status was evaluated with the modified body mass index (s‐albumine × BMI). Key Results  Gastric retention was found in about one‐third of the patients. A weak correlation was found between the scintigraphic gastric emptying rate and both the sympathetic (rs = −0.397, P 
ISSN:1350-1925
1365-2982
1365-2982
DOI:10.1111/j.1365-2982.2012.01991.x