ST depression at caesarean section and the relation to oxytocin dose. A randomised controlled trial

Objective  To investigate whether there is a difference in occurrence of electrocardiogram changes suggestive of myocardial ischaemia between two different doses of oxytocin. Design  Double‐blind randomised controlled trial Setting  University hospital in Sweden. Population  A total of 103 healthy w...

Full description

Saved in:
Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2010-01, Vol.117 (1), p.76-83
Main Authors: Jonsson, M, Hanson, U, Lidell, C, Nordén‐Lindeberg, S
Format: Article
Language:English
Subjects:
Adult
Anesthesia, Obstetrical - methods
Anesthesia, Spinal - methods
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - physiopathology
Blood pressure
Blood Pressure - drug effects
Caesarean section
Cesarean Section
Clinical trials
Dose-Response Relationship, Drug
Double-Blind Method
Drug dosages
Drug therapy
Electrocardiography
Electrocardiography, Ambulatory - drug effects
Female
heart
Humans
hypotension
ischaemia
ischemia
MEDICIN
MEDICINE
Obstetrics and Gynaecology
Obstetrik och gynekologi
Oxytocics - administration & dosage
Oxytocics - adverse effects
oxytocin
Oxytocin - administration & dosage
Oxytocin - adverse effects
Pregnancy
regional anaesthesia
Troponin I - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective  To investigate whether there is a difference in occurrence of electrocardiogram changes suggestive of myocardial ischaemia between two different doses of oxytocin. Design  Double‐blind randomised controlled trial Setting  University hospital in Sweden. Population  A total of 103 healthy women undergoing elective caesarean section under spinal anaesthesia. Methods  The participants were randomised to 5 or 10 units of oxytocin, given as an intravenous bolus. A Holter monitor was used to record electrocardiograms and non invasive blood pressure and heart rate (HR) was monitored. A blood sample was obtained 12‐hour postoperatively. Main outcome measures  Depression of the ST segment. Secondary outcomes: symptoms, Troponon I levels, mean arterial pressure (MAP), HR and blood loss. Results  There was a significant difference in occurrence of ST depressions associated with oxytocin administration, 4 (7.7%) with 5 and 11 (21.6%) with 10 units, P 
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2009.02356.x