The Anionic Boron Cluster (B(12)H(11)SH)(2-) as a Means To Trigger Release of Liposome Contents

Triggered release . Liposomes are novel carriers for pharmaceutical agents and can be triggered to release their contents by the addition of B 12 H 11 SH, a compound in clinical use. As systemic toxicity is decreased relative to the free drug, liposomal drugs can therefore be administered in higher...

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Bibliographic Details
Published in:ChemMedChem 2007, Vol.2 (1), p.51
Main Authors: Gabel, Detlef, Awad, Doaa, Schaffran, Tanja, Radovan, Diana, Daraban, Daniel, Damian, Luminita, Winterhalter, Mathias, Karlsson, Göran, Edwards, Katarina
Format: Article
Language:English
Subjects:
boranes
calorimetry
cellular toxicity
FARMACI
leakage
liposomes
PHARMACY
Online Access:Get full text
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Summary:Triggered release . Liposomes are novel carriers for pharmaceutical agents and can be triggered to release their contents by the addition of B 12 H 11 SH, a compound in clinical use. As systemic toxicity is decreased relative to the free drug, liposomal drugs can therefore be administered in higher concentrations before dose-limiting side effects are met. Thus, liposome-encapsulated drugs may be of great value in the therapy of diseases.
ISSN:1860-7179
DOI:10.1002/cmdc.200600227