Evaluation of bilayer disks as plant cell membrane models in partition studies

We have studied the partitioning of a set of phenolic compounds used as lignin precursor models into lipid bilayer disks and liposomes. The bilayer disks are open bilayer structures stabilized by polyethylene glycol-conjugated lipids. Our results indicate that disks generate more accurate partition...

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Bibliographic Details
Published in:Analytical biochemistry 2007-05, Vol.364 (2), p.145-152
Main Authors: Boija, Elisabet, Lundquist, Anna, Edwards, Katarina, Johansson, Gunnar
Format: Article
Language:English
Subjects:
Cell Membrane - chemistry
Cell-Free System - chemistry
Chemistry
Chemistry, Physical - methods
Cholesterol - chemistry
Immobilized liposome chromatography
Kemi
Lignin
Lipid bilayer disks
Lipid Bilayers - chemistry
Liposomes
Liposomes - chemistry
Membranes, Artificial
Models, Biological
Models, Chemical
Molecular Structure
Monolignol
NATURAL SCIENCES
NATURVETENSKAP
Partitioning
Phenols
Plant cell membrane lipids
Plant Cells
Polyethylene Glycols - chemistry
Surface Properties - drug effects
Thermodynamics
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Summary:We have studied the partitioning of a set of phenolic compounds used as lignin precursor models into lipid bilayer disks and liposomes. The bilayer disks are open bilayer structures stabilized by polyethylene glycol-conjugated lipids. Our results indicate that disks generate more accurate partition data than do liposomes. Furthermore, we show that the partitioning into the membrane phase is reduced slightly if disks composed of 1,2-distearoyl- sn-glycero-3-phosphocholine and cholesterol are exchanged for disks with a lipid composition mimicking that of the root tissue of Zea mays L.
ISSN:0003-2697
1096-0309
1096-0309
DOI:10.1016/j.ab.2007.02.012