HYALURONIC ACID MODULATES CELL PROLIFERATION UNEQUALLY IN INTRASYNOVIAL AND EXTRASYNOVIAL RABBIT TENDONS IN VITRO

As tendons differ in biochemical composition and cellular capacities, we have compared dose response effects of hyaluronic acid on cell proliferation and synthesis of matrix components in intermediate and proximal segments of intrasynovial deep flexor tendons and extrasynovial peroneus rabbit tendon...

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Bibliographic Details
Published in:Journal of hand surgery, British volume British volume, 2000-04, Vol.25 (2), p.183-187
Main Authors: WIIG, M, ABRAHAMSSON, S.-O
Format: Article
Language:English
Subjects:
Animals
Cell Division - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Hyaluronic Acid - pharmacology
In Vitro Techniques
Rabbits
Tendons - cytology
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Summary:As tendons differ in biochemical composition and cellular capacities, we have compared dose response effects of hyaluronic acid on cell proliferation and synthesis of matrix components in intermediate and proximal segments of intrasynovial deep flexor tendons and extrasynovial peroneus rabbit tendons in vitro. Compared with matched control tendons, hyaluronic acid inhibited cell proliferation in intermediate and proximal intrasynovial flexor tendon segments at the concentrations of 0.1–2.0 mg/ml and 0.5–2.0 mg/ml respectively, but in extrasynovial tendon segments only at the concentration of 0.5 mg/ml. Hyaluronic acid did not affect synthesis of proteoglycan, collagen and non-collagen protein in either type of tendon. These results show that hyaluronic acid modulates cell proliferation unequally in intra- and extrasynovial tendons without affecting the synthesis of matrix components in the two types of tendons, indicating differential hyaluronic acid sensitivity and a possible mechanism of action.
ISSN:0266-7681
1532-2211
DOI:10.1054/jhsb.1999.0354