Hemodynamic Effect of Iopromide in Pancreas-Duodenum Transplanted Rats

Background: Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation, especially in acute pancreatitis. Purpose: To evaluate the effects of the low-osmolar CM iopromide on total pancreatic and especially islet blood perfusion after whole pancreas transpla...

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Bibliographic Details
Published in:Acta radiologica (1987) 2007-12, Vol.48 (10), p.1125-1130
Main Authors: Linder, G., Carlsson, P. -O., Källskog, Ö., Hansell, P., Jansson, L., Källskog, V.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Contrast Media - administration & dosage
Contrast Media - pharmacology
Duodenum - transplantation
Gastroenterology. Liver. Pancreas. Abdomen
graft pancreatitis
Intravascular contrast media
Iohexol - administration & dosage
Iohexol - analogs & derivatives
Iohexol - pharmacology
islet blood perfusion
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
MEDICIN
MEDICINE
Other diseases. Semiology
Pancreas - blood supply
Pancreas - drug effects
Pancreas Transplantation
pancreatic blood perfusion
Pancreatitis
Rats
Rats, Wistar
Regional Blood Flow - drug effects
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Summary:Background: Radiological contrast media (CM) have been suggested to be able to impair pancreatic microcirculation, especially in acute pancreatitis. Purpose: To evaluate the effects of the low-osmolar CM iopromide on total pancreatic and especially islet blood perfusion after whole pancreas transplantation. Material and Methods: Rats receiving a pancreas-duodenum transplantation 2 days earlier, i.e., with graft pancreatitis, were injected with iopromide. Blood perfusion measurements were then made with a microsphere technique. Results: The graft blood perfusion was decreased in control rats when compared to the endogenous pancreas. Administration of iopromide increased both total pancreatic and islet blood perfusion in the grafted pancreas, but not in the endogenous gland. No effects on blood perfusion to either the native or transplanted duodenum were seen after iopromide administration. Conclusion: Iopromide increases the blood perfusion of a whole pancreas transplant 2 days after implantation, i.e., when graft pancreatitis is present. The consequences of this CM-induced hyperperfusion for graft pancreatic function remain to be established.
ISSN:0284-1851
1600-0455
1600-0455
DOI:10.1080/02841850701611110