Estrogen receptor-like immunoreactivity in the medullary and spinal dorsal horn of the female rat

Using an immunohistochemical technique, we demonstrate that large numbers of neurons in the laminar spinal trigeminal nucleus and spinal gray matter of the female rat express estrogen receptors (ER). Densely packed ER-immunoreactive neurons were present in lamina II, but labeled neurons were also pr...

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Bibliographic Details
Published in:Neuroscience letters 1995-08, Vol.196 (1), p.25-28
Main Authors: Amandusson, Åsa, Hermanson, Ola, Blomqvist, Anders
Format: Article
Language:English
Subjects:
Anatomy
Animals
Biological and medical sciences
Brain Stem - immunology
Central nervous system
Clinical neurophysiology
Female
Fundamental and applied biological sciences. Psychology
Fysiologi
Fysiologi och farmakologi
Gonadal hormones
Immunohistochemistry
Klinisk neurofysiologi
MEDICIN
MEDICINE
Neurons - immunology
Pain
Physiology
Physiology and pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Estrogen - immunology
Spinal cord
Spinal Cord - immunology
Spinal Cord - metabolism
Spinal trigeminal nucleus
Substantia gelatinosa
Vertebrates: nervous system and sense organs
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Summary:Using an immunohistochemical technique, we demonstrate that large numbers of neurons in the laminar spinal trigeminal nucleus and spinal gray matter of the female rat express estrogen receptors (ER). Densely packed ER-immunoreactive neurons were present in lamina II, but labeled neurons were also present in lamina I, the neck of the dorsal horn, and in lamina X. Labeling was present throughout the length of the spinal cord, with the exception of segments caudal to S1, which were unlabeled. The distribution of ER-containing neurons to areas that are involved in processing of primary afferent nociceptive information suggests that the pain modulatory effects of estrogen may be exerted at the spinal level.
ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/0304-3940(95)11828-K