Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): Three peptides and six receptor subtypes

• Published in: General and comparative endocrinology 2012-07, Vol.177 (3), p.322-331
• Main Authors: Sundström, G, Xu, B, Larsson, T.A, Heldin, J, Bergqvist, C.A, Fredriksson, R, Conlon, J.M, Lundell, I, Denver, R.J, Larhammar, D
• Format: Article
• Language: English
• Subjects: Amniota; Animals; Anura; appetite; blood; brain; chickens; Endocrinology & Metabolism; evolution; feeding behavior; frogs; G-protein coupled receptors; G-protein-coupled receptor; genes; heart; mammals; messenger RNA; muscles; neuropeptide Y; Neuropeptide Y - classification; Neuropeptide Y - genetics; Neuropeptide Y - metabolism; NPY; Pancreatic polypeptide; peptide receptors; Peptide YY - classification; Peptide YY - genetics; Peptide YY - metabolism; Phylogeny; Pipidae; Pipidae - genetics; Pipidae - metabolism; PYY; Receptors, G-Protein-Coupled - classification; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, Neuropeptide Y - classification; Receptors, Neuropeptide Y - genetics; Receptors, Neuropeptide Y - metabolism; reverse transcriptase polymerase chain reaction; Silurana tropicalis; small intestine; Xenopus tropicalis
• ISSN: 0016-6480; 1095-6840; 1095-6840
• DOI: 10.1016/j.ygcen.2012.04.027

Highlights ► The Western clawed frog has six of the ancestral seven gnathostome receptors. ► Binding studies show interesting differences to mammals in peptide–receptor preferences. ► The peptides and receptors are widely expressed, notably in skin. ► NPY was detected in brain like in all other vertebrates investigated. ► PYY was not detected in brain, as in mammals but in contrast to fish, nor was PP.