Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009

• Published in: Journal of the American Academy of Dermatology 2010-10, Vol.63 (4), p.607-641
• Main Authors: Oji, Vinzenz, MD, Tadini, Gianluca, MD, Akiyama, Masashi, MD, PhD, Blanchet Bardon, Claudine, MD, Bodemer, Christine, MD, PhD, Bourrat, Emmanuelle, MD, Coudiere, Philippe, PharmD, DiGiovanna, John J., MD, Elias, Peter, MD, Fischer, Judith, MD, PhD, Fleckman, Philip, MD, Gina, Michal, MD, Harper, John, MD, FCRCP, FRCPCH, Hashimoto, Takashi, MD, Hausser, Ingrid, PhD, Hennies, Hans Christian, PhD, Hohl, Daniel, MD, PhD, Hovnanian, Alain, MD, PhD, Ishida-Yamamoto, Akemi, MD, PhD, Jacyk, Witold K., MD, Leachman, Sancy, MD, PhD, Leigh, Irene, MD, FRCP, FMedSci, Mazereeuw-Hautier, Juliette, MD, PhD, Milstone, Leonard, MD, Morice-Picard, Fanny, MD, Paller, Amy S., MS, MD, Richard, Gabriele, MD, FACMG, Schmuth, Matthias, MD, Shimizu, Hiroshi, MD, PhD, Sprecher, Eli, MD, PhD, Van Steensel, Maurice, MD, PhD, Taïeb, Alain, MD, Toro, Jorge R., MD, Vabres, Pierre, MD, Vahlquist, Anders, MD, PhD, Williams, Mary, MD, Traupe, Heiko, MD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; autosomal recessive congenital ichthyosis; Biological and medical sciences; Child; Congresses as Topic; Dermatologi och venerologi; Dermatologi och venerologi, klinisk genetik, invärtesmedicin; Dermatologic Agents - therapeutic use; Dermatology; Dermatology and venerology; Dermatology and venerology,clinical genetics, internal medicine; Dyskeratosis; epidermolytic ichthyosis; Female; France; Gene Expression Regulation; Genetic Predisposition to Disease; genetics; histology; Humans; Ichthyosiform Erythroderma, Congenital - classification; Ichthyosiform Erythroderma, Congenital - drug therapy; Ichthyosiform Erythroderma, Congenital - genetics; Ichthyosis - classification; Infant; Infant, Newborn; keratinopathic ichthyosis; Male; Medical sciences; MEDICIN; MEDICINE; mendelian disorders of cornification; Practice Guidelines as Topic - standards; Prognosis; Severity of Illness Index; superficial epidermolytic ichthyosis; Terminology as Topic; ultrastructure; Young Adult
• ISSN: 0190-9622; 1097-6787; 1097-6787
• DOI: 10.1016/j.jaad.2009.11.020

Background Inherited ichthyoses belong to a large, clinically and etiologically heterogeneous group of mendelian disorders of cornification, typically involving the entire integument. Over the recent years, much progress has been made defining their molecular causes. However, there is no internationally accepted classification and terminology. Objective We sought to establish a consensus for the nomenclature and classification of inherited ichthyoses. Methods The classification project started at the First World Conference on Ichthyosis in 2007. A large international network of expert clinicians, skin pathologists, and geneticists entertained an interactive dialogue over 2 years, eventually leading to the First Ichthyosis Consensus Conference held in Sorèze, France, on January 23 and 24, 2009, where subcommittees on different issues proposed terminology that was debated until consensus was reached. Results It was agreed that currently the nosology should remain clinically based. “Syndromic” versus “nonsyndromic” forms provide a useful major subdivision. Several clinical terms and controversial disease names have been redefined: eg, the group caused by keratin mutations is referred to by the umbrella term, “keratinopathic ichthyosis”–under which are included epidermolytic ichthyosis, superficial epidermolytic ichthyosis, and ichthyosis Curth-Macklin. “Autosomal recessive congenital ichthyosis” is proposed as an umbrella term for the harlequin ichthyosis, lamellar ichthyosis, and the congenital ichthyosiform erythroderma group. Limitations As more becomes known about these diseases in the future, modifications will be needed. Conclusion We have achieved an international consensus for the classification of inherited ichthyosis that should be useful for all clinicians and can serve as reference point for future research.