Automated synthesis of F-18-labelled analogs of metomidate, vorozole and harmine using commercial platform

Three F-18-labelled PET tracers, 2-[F-18]fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([F-18]FETO), 6-[(S)-(4-chlorophenyl)-(1H)-1,2,4-triazol-1-yl)methyl]-1-(2-[F-18]fluor oethyl)-1H-benzotriazole ([F-18]FVOZ) and 7-[2-(2-[F-18]fluoroethoxy)ethoxy]-1-9H-beta-carboline ([F-18]FHAR)...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2010-03, Vol.53 (3-4), p.169
Main Authors: Rahman, Obaidur, Erlandsson, Maria, Blom, Elisabeth, Långström, Bengt
Format: Article
Language:English
Subjects:
[F-18]FETO
[F-18]FHAR
[F-18]FVOZ
automated synthesis
Chemistry
F-18-labelling
Kemi
NATURAL SCIENCES
NATURVETENSKAP
PET
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Summary:Three F-18-labelled PET tracers, 2-[F-18]fluoroethyl 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate ([F-18]FETO), 6-[(S)-(4-chlorophenyl)-(1H)-1,2,4-triazol-1-yl)methyl]-1-(2-[F-18]fluor oethyl)-1H-benzotriazole ([F-18]FVOZ) and 7-[2-(2-[F-18]fluoroethoxy)ethoxy]-1-9H-beta-carboline ([F-18]FHAR) were synthesized by a one-step nucleophilic fluorination using the automated commercial platform TRACERLab FXFN. The labelled products were obtained with 16-20% isolated decay corrected radiochemical yields after 70-75 min synthesis time. The radiochemical and chemical purities were more than 98% in all cases. The synthesis using commercial platform may make these tracers more accessible for clinical research.
ISSN:1099-1344
0362-4803
DOI:10.1002/jlcr.1742