Proteolytic cascades and their involvement in invertebrate immunity

Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation,...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2010-10, Vol.35 (10), p.575-583
Main Authors: Cerenius, Lage, Kawabata, Shun-ichiro, Lee, Bok Luel, Nonaka, Masaru, Söderhäll, Kenneth
Format: Article
Language:English
Subjects:
Animals
Biologi
Biologi med inriktning mot jämförande fysiologi
Biology
Biology with specialization in Comparative Physiology
Cell and molecular biology
Cell- och molekylärbiologi
coagulation
complement evolution
Enzyme Activation
Immunity, Innate
Immunologi
Immunology
Invertebrates - enzymology
Invertebrates - immunology
Models, Molecular
NATURAL SCIENCES
NATURVETENSKAP
Peptide Hydrolases - genetics
Peptide Hydrolases - immunology
Peptide Hydrolases - metabolism
Phylogeny
prophenoloxidase
toll receptor
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Summary:Bacteria and other potential pathogens are cleared rapidly from the body fluids of invertebrates by the immediate response of the innate immune system. Proteolytic cascades, following their initiation by pattern recognition proteins, control several such reactions, notably coagulation, melanisation, activation of the Toll receptor and complement-like reactions. However, there is considerable variation among invertebrates and these cascades, although widespread, are not present in all phyla. In recent years, significant progress has been made in identifying and characterizing these cascades in insects. Notably, recent work has identified several connections and shared principles among the different pathways, suggesting that cross-talk between them may be common.
ISSN:0968-0004
1362-4326
1362-4326
DOI:10.1016/j.tibs.2010.04.006