Measurement of direct ethanol metabolites suggests higher rate of alcohol use among pregnant women than found with the AUDIT—a pilot study in a population-based sample of Swedish women

Objectives The objective of the study was to investigate whether biomarkers of alcohol consumption would provide additional information to the use of a validated alcohol questionnaire in pregnant women. Study Design One hundred three pregnant women were included in the study. The women completed the...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2008-04, Vol.198 (4), p.407.e1-407.e5
Main Authors: Wurst, Friedrich Martin, MD, PhD, Kelso, Erika, MD, Weinmann, Wolfgang, PhD, Pragst, Fritz, PhD, Yegles, Michel, PhD, Sundström Poromaa, Inger, MD, PhD
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
alcohol
Alcohol Drinking
Alcohol Use Disorders Identification Test
Alcoholism
Alcoholism - diagnosis
Alcoholism - urine
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biomarkers - analysis
direct ethanol metabolites
Esters - analysis
Ethanol - metabolism
Ethanol - urine
Fatty Acids - analysis
Female
Glucuronates - analysis
Gynecology. Andrology. Obstetrics
Hair - chemistry
Humans
Medical sciences
MEDICIN
MEDICINE
Obstetrics and Gynecology
Pilot Projects
Pregnancy
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Surveys and Questionnaires
Sweden
Toxicology
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Summary:Objectives The objective of the study was to investigate whether biomarkers of alcohol consumption would provide additional information to the use of a validated alcohol questionnaire in pregnant women. Study Design One hundred three pregnant women were included in the study. The women completed the Alcohol Use Disorders Identification Test (AUDIT) questionnaire, and a urine and hair sample was collected. The urine samples were used for determination of ethyl glucuronide (EtG) and ethyl sulfate and the hair samples for EtG and fatty acid ethyl esters (FAEE). Results Twenty-six women (25.2%) were identified as possible alcohol consumers by the combined use of AUDIT and direct ethanol metabolites. Seven subjects had EtG or FAEE levels in hair highly suspicious of heavy drinking, but only 1 of these were positive according to the AUDIT questionnaire Conclusion The combined use of the AUDIT questionnaire and direct ethanol metabolites appear to identify more potential alcohol consumers among pregnant women than does the sole use of the AUDIT questionnaire.
ISSN:0002-9378
1097-6868
1097-6868
DOI:10.1016/j.ajog.2007.10.801